Molecular Biology

Synthesis of a phosphatase inhibitor reveals an unexpected selectivity profile

Published in Cancer Weekly, November 25th, 2003

A large number of different phosphatases, enzymes that split phosphate groups off proteins, play a key role in the regulation of cellular processes. Interest in substances that selectively inhibit specific phosphatases is thus correspondingly high.

German researchers were recently surprised when they "reproduced" a previously described phophatase inhibitor with known antitumor activity. The inhibitor had a completely different selectivity profile than that previously ascribed to it - possibly making the substance even more interesting.

Alois Furstner and Fabian Feyen of the Max-Planck-Institute for Carbon Research in Mulheim an der Ruhr, Germany, and...

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Source: Cancer Weekly (2003-11-25)

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