Published in Cancer Weekly, November 25th, 2003
"Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory component of the transforming growth factor -beta receptor complex and is involved in vascular development and remodel," scientists in Italy report.
"Quantication of intratumoral microvessel density by CD105 staining and of circulating soluble CD105 has been suggested to...
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