Antitumor Drugs

Two CD95 tumor classes with different sensitivities to antitumor drugs

Published in Cancer Weekly, December 2nd, 2003

Two CD95 tumor classes with different sensitivities to antitumor drugs. According to recent research from the United States, "CD95 type I and II cells differ in their dependence on mitochondria to execute apoptosis, because antiapoptotic members of the Bcl-2 family render only type II cells resistant to death receptor-induced apoptosis.

"They can also be distinguished by a more efficient formation of the death-inducing signaling complex in type I cells. We have identified a soluble form of CD95 ligand (S2) that is cytotoxic to type II cells but does not kill type I cells," wrote A. Algeciras-Schimnich and colleagues, University of Chicago, Ben May Cancer Research...

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Source: Cancer Weekly (2003-12-02)

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