Gene Transfer
SMAD4 gene therapy halts the invasiveness of pancreatic adenocarcinoma cells
Published in Cancer Weekly, December 2nd, 2003
"SMAD4 is a critical cofactor in signal transduction pathways activated in response to transforming growth factor-beta (TGF-beta)-related ligands, regulating cell growth and differentiation. The roles played by SMAD4 inactivation in tumors highlighted it as a tumor-suppressor gene. However, restoration of the TGF-beta antiproliferative pathway following SMAD4 gene transfer in null-tumor cell lines is controversial," investigators in Japan report.
"Herein, we report the inhibitory effects of SMAD4 on pancreatic tumor invasion and angiogenesis. Adenoviral transfer of this...
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Source: Cancer Weekly (2003-12-02)
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