Lung Cancer
Methylation of genes in the upper aerodigestive tract epithelium of smokers
Published in Cancer Weekly, December 16th, 2003
According to recent research published in the International Journal of Cancer, "an important method for silencing tumor suppressor genes in cancers is by aberrant methylation (referred to as methylation) of CpG islands in gene promoter regions.
"In lung cancer, methylation of the genes retinoic acid receptor beta-2 (RARbeta-2), CDH13 (H-cadherin), p16(INK4a) (p16), RASSFIA (RAS association domain family 1) is frequent. Thus, we investigated methylation of these genes in...
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Source: Cancer Weekly (2003-12-16)
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