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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . December 23rd, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Larynx Cancer - New standard for voice-saving care of patients introduced

Multiple Myeloma - Origin of bone marrow cancer found in rare stem cell

Colorectal Cancer - Calcium and vitamin D collaborate to reduce risk

Gene Therapy - CD46 acts as cellular receptor for group B adenoviruses

Prostate Cancer - Gene therapy and radiation combination shows promise in prostate cancer study

Antifungal Therapy - Pediatric patients may benefit from voriconazole for invasive aspergillosis

Antitumor Radiotherapy - Leaky radiohalogen labels used in targeting tumors can be modified for retention

Brain Disease - Water diffusion in brain disease and ischemia can be detected by diffusion MRI

Breast Cancer - Better prognosis for HRT users more likely due to frequent screening

Breast Cancer - Breast tumors can be organized into subclasses based on markers; may aid therapy

Breast Cancer - Breast-conserving therapy offers good outcome if criteria are met

Breast Cancer - CAD software improves breast ultrasound, digital mammograms

Breast Cancer - CYPRED catalyzes doxorubicin in liver; not active against breast cancer cells

Breast Cancer - Clinical images of blood flow in breast may facilitate cancer diagnosis

Breast Cancer - Comparison study finds no survival difference between fulvestrant, anastrozole

Breast Cancer - Drug that eases tamoxifen side effect may also hinder its effectiveness

Breast Cancer - EGFR status linked to poor survival in patients with advanced disease

Breast Cancer - FDA clears new method for managing non-cancerous breast lumps

Breast Cancer - New genetic test may help patients make chemotherapy decision

Breast Cancer - New scanner can detect early signs of disease

Breast Cancer - Outpatient procedure shrinks benign breast lumps

Breast Cancer - Pennsylvania Breast Cancer Coalition to receive research grant

Breast Cancer - Scientists find better way to predict disease outcome following surgery

Breast Cancer - Study looks at etiological role of early exposure to household chemicals

Breast Cancer - Study shows improved survival rates, time to disease progression with docetaxel

Breast Cancer - Surgery without radiation inadequate for DCIS, study shows

Breast Cancer - Tumor vaccine to begin clinical trials

Business & Finance - Digene added to NASDAQ Biotech index

Cancer Detection - Detection companies announce expanded partnership

Cancer Detection - Detection companies join to expand computer-aided detection

Cancer Epidemiology - The viral etiology of hepatocellular carcinoma in Greece has changed

Cancer Genomics - The HC gp-39 gene is a biomarker for progression in astrocytic glioma

Cancer Imaging - Future cancer imaging methods can use mammography as a learning base

Cancer Prevention - Angiogenesis is one of several activities targeted by vitamin D and its analogs

Cancer Proteomics - Oncostatin-M causes astroglioma cells to produce angiogenic growth factor

Cancer Therapy - Advexin therapy to be combined with surgery in phase II trial

Cancer Therapy - CV-IBS provides early warning of doxorubicin-induced heart damage

Cancer Therapy - Company announces phase I/II trial development of MDX-214

Cancer Therapy - Company reports on monoclonal antibody therapeutics advancements

Cancer Therapy - Endothelial progenitor cells carry gene therapy to solid tumors

Cancer Therapy - Technique kills cancerous cells, leaves healthy cells intact

Cancer Therapy - Thrombospondin 1 augments low-dose metronomic chemotherapy

Cancer Vaccine - Tumor antigen plus GM-CSF ends immunological ignorance to tumor antigen

Cervical Cancer - Cervical cancer prevention and treatment reviewed

Cervical Cancer - HPV testing could be future strategy for primary screening

Cervical Cancer - HPVDNAChip detects multiple human papillomavirus strains in cancer specimens

Clinical Trials - Company summarizes irofulven clinical data

Colon Cancer - Company reports on bispecific antibody technology

Colon Cancer - Human colorectal cancer treated with 5-FU, anticancer drugs, by gene profiling

Colon Cancer - License agreement made for computer-aided detection tools in colonoscopy

Colon Cancer Screening - 3-D virtual colonoscopy is more sensitive than conventional procedure

Colorectal Cancer - Erbitux cancer drug approved and available in Switzerland

Colorectal Cancer - NDS filed with Health Canada for Erbitux

Colorectal Cancer - Study examines risk factors associated with colorectal cancer

DNA Damage - DNA damage plays role in genetic predisposition to arsenic cytotoxicity

Data Management - Encoded CAP Cancer Checklists help pathologists report common forms of disease

Dermatology - Pulsed dye laser treatment of glomangiomyoma results in complete pain relief

Drug Development - Derivatives of a potent anti-herpes agent improve the efficacy of gene therapy

Drug Development - Microtubule inhibitors given as anticancer therapy are improving

Drug Development - New sarcodictyin/eleutherobin analogs have less cytotoxicity than paclitaxel

Endocrinology - 17 Beta-estradiol regulates cytokine release from macrophages

Endocrinology - Small-molecule inhibitors override the angiogenic potential of thyroid cancer

Ethnic Variation - The CD1D gene has haplotypes that differ in prevalence between ethnic groups

Finance - Cancer diagnostics company closes $4 million bridge financing

Finance - Surgical product company completes equity placement

Gastric Cancer - Fecal samples from gastric cancer, even hyperplasia tend to be gp87 positive

Gastric Carcinoma - Gastric cancer with high MIP-1 beta expression correlate with metastasis risk

Genomics - New publication of research into therapeutic treatments for cancer

Gynecology - Patients with borderline nuclear change in cervical smears warrant follow-up

Head and Neck Cancers - Photodynamic therapy used to treat cancer of the head and neck

Helicobacter Pylori - Purified H. pylori CagA, HspB proteins can induce gastric cell division

Hematologic Cancer - HTLV-1 Tax oncoprotein inhibits hematopoiesis

Hepatocellular Carcinoma - Lonidamine increases tamoxifen, other antiproliferative activity on HCC

Hodgkin Disease - Some patients develop heart problems years after radiation treatment

Immunoliposomes - PEG-modified liposomal doxorubicin with GAH targets GI cancer cells with antigen

Leukemia - Allelic evolution of C/EBP-alpha mutations occur in myeloid leukemia

Leukemia - Three months is too soon to judge a CML patient's response to Gleevec

Leukemia Therapy - Allo-SCT effective for pediatric CML patients

Leukemia Therapy - High stem-cell dose hastens platelet recovery after auto-SCT

Liver Cancer - Diagnostic test licensed from Toronto hospital

Liver Cancer - Rita Medical shares climb on encouraging test results for device

Liver Cancer Risk Factor - Hepatitis B immunization reduces incidence of hepatocellular carcinoma

Lung Cancer - Annual CT screening detects early-stage lung cancers

Lung Cancer - Antisense oligomer controls growth factor to halt non-small cell lung cancer

Lung Cancer - Company publishes preclinical results describing NC 381, an antitumor agent

Lung Cancer - Computer-aided detection system improves lung nodule detection

Lung Cancer - Enrollment completed in trial of Xyotax for high-risk patients

Lung Cancer - Female smokers are twice as likely as male smokers to develop deadly disease

Lung Cancer - New study reinforces need for early detection of lung cancer

Lung Cancer - New technology enhances lung cancer detection

Lung Cancer - Non-small cell lung cancer response to Taxol linked to P-glycoprotein

Lung Cancer - PET imaging displays transgene distribution in the lungs

Lung Cancer - Researchers quantify cancer risks from secondhand smoke

Lung Cancer - Risk for small cell lung cancer increases with some CYP3A alleles and smoke dose

Lung Disease - Detroit physician says lung scan may help smokers kick the habit

Lung Disease - International experts hope more attention goes to lung disease

Lymphoma Therapy - Stem-cell autotransplantation effective against nasal NK/T-cell lymphoma

Melamona - Vitamin C uses a caspase-independent pathway for apoptosis of melanoma cells

Melanoma - Gene explains why men are at higher risk of skin cancer

Mergers and Acquisitions - IMPAC to purchase PowerPath pathology, cancer registry information businesses

Metastasis - Cancer biopsies on the dot can clarify prognosis

Metastasis - Unraveling a protein, researchers uncover mechanics of anticancer agent

Molecular Biology - Chromosomes are "nibbled" before they fuse

Monoclonal Antibodies - Rituximab therapy holds promise in hematological disease, non-Hodgkin lymphoma

Muscular Disease - Partnership announced to find treatment for spinal muscular atrophy

Mutagenesis - A new assay detects genetic variants associated with colorectal cancer risk

Nerve Growth - Securin, low in fetal brain, correlates with lack of adult neural proliferation

Neurinomas - Acoustic neurinomas require monitoring, surgery before hearing damage occurs

New Products - NewsRx expands to 100 titles in Health Law and Business

Nutrition - "Musical fruit" rich source of healthy antioxidants; black beans highest

Obesity - Physicians tapped to help combat obesity

Oncology - Alpha-fetoprotein mRNA does not predict liver cancer in cirrhosis patients

Oncology - Angiogenesis peaks at two points during adenocarcinoma progression

Oncology - Biopharmaceutical NCE's expand oncology franchise

Oncology - Biopharmaceutical company partners with NIH to develop oncology compound

Oncology - Biotech company receives Canadian patent for potential cancer treatment

Oncology - New biomarker for advanced childhood brain cancer discovered

Oncology - Novogen granted patent for anticancer drug phenoxodiol

Oncology - Preclinical results positive for vascular targeting anticancer compound

Oncology - Revised guidelines show changes for breast cancer treatment

Oncology - Study data presented on agent for malignant glioma

Oncology - Study supports early use of drug in treatment of breast cancer

Oncology - The urokinase plasminogen activator system strengthens cancer metastasis

Oncology - VEGF-C links with low survival in esophageal squamous cell carcinoma patients

Orthopedic Surgery - Limb salvage techniques are effective in pediatric bone sarcomas

Pain Management - New product development program initiated for severe chronic pain

Patents - Broad patent granted for use of immune stimulatory CpG oligonucleotides

Personnel - Biopharmaceutical company names new executive for commercial development

Personnel - Prostate Cancer Foundation names new advisor and directors

Prostate Cancer - Elderly men receiving excessive prostate screening, study suggests

Prostate Cancer - Higher stromal density, desmin, SMA are indicators for recurrence-free survival

Pruritis - Pulsed dye laser therapy can resolve untreatable pruritis in ALHE patients

Radiation Therapy - 3-D image-guided radiation therapy system receives FDA clearance

Radiotherapy - Pelvic radiation dose must be altered if high atomic number prostheses are near

Recombinant Research -  Myxococcus xanthus yields epothilone analogues with anticancer activity

Reimbursement - HealthBridge to manage Ganite maker's patient assistance program

Renal Cancer - Overexpressed von Hippel-Lindau tumor suppressor protein diminishes cancer

Sexually Transmitted Diseases - STDs could increase risk of cervical cancer

Skin Cancer - Drug can reduce sun damage by 50% for fair-skinned people

Skull Base Tumors - Microsurgery works as well or better than radiosurgery on skull base tumors

Solid Tumors - Preliminary phase I data presented on HYB2055

Stem-Cell Research - HOXB4 homeoprotein expands human hematopoietic stem cells

Stem-Cell Transplantation - HA-8 disparity linked to clinically insignificant risk in acute GVHD risk

Stem-Cell Transplantation - Long-term PBSC cryopreservation possible for germ cell cancer patients

Stock Market - Gene therapy company to list on the American Stock Exchange

Targeted Therapy - HPMA copolymer-bound doxorubicin effectively targets leukemia with monoclonal B1

Tobacco Use - Nicotine stimulates new vessel growth and encourages tumor growth

Transplantation - Adefovir offers rescue after hepatitis B virus reinfections of liver grafts

Tumor Therapy - Noninvasive surgical tool for the treatment of tumors being studied

Tumors - Progress reported on anticancer development program

X-Rays - Single cell irradiation in culture shows bystander nonirradiated cells also die

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