Cancer Weekly

Genomics - Mining of the human genome database can yield genes of therapeutic interest

Gulf War Syndrome - Are Gulf War veterans getting better?

Gynecology - Platelet-derived endothelial cell growth factor marks ovarian cancer behavior

Gynecology - The silybin-phosphatidylcholine complex IdB 1016 might treat ovarian cancer

Healthcare Performance - Leadership clarity and team innovation affects healthcare outcome

Helicobacter Pylori - A complete H. pylori cag pathogenicity island confers greater disease

Hepatocellular Carcinoma - More studies needed to reveal COX2 inhibitors affect on liver disease

Imaging - Company reports data on ProstaScint molecular imaging agent

Imaging - New dynamic PET technique offers greater comfort for cancer patients

Immunology - Transfected tumor cells boost antitumor responses in lung cancer patients

Intrahepatic Cholangiocarcinoma - F-18-FDG PET helps detect primary lesion in hilar, peripheral cholangiocarcinoma

Knee Rotationplasty - Rotationplasty offers durable reconstruction after knee tumor resection

Leukemia - AP23464 is effective in Gleevec-resistant leukemia cells

Leukemia - AT islands in fragile sites can function as matrix attachment regions

Leukemia - First patient enters pivotal phase II study for clofarabine

Leukemia - Higher dose of Gleevec leads to increased remission in CML patients

Leukemia - New assay will help diagnose, monitor therapy for cancer patients

Leukemia - PTEN expression in leukemic T cells leads to reduced proliferation

Leukemia - Tipifarnib shows activity in previously untreated poor-risk AML and MDS

Liver Cancer - Early arterial occlusion affects survival in patients with implanted chemo port

Lung Cancer - ATP may prolong survival in weight-losing patients with stage III disease

Lung Cancer - Air quality data analysis system showcases asbestos lung cancer mortality data

Lung Cancer - Biotech company in-licenses phase I anticancer drug from Sankyo

Lung Cancer - DNA analysis may help refine sputum exams, improve early lung cancer detection

Lung Cancer - FDA grants fast track designation for non-small cell lung cancer therapy

Lung Cancer - Parathyroid hormone-related protein could promote cancer progression in vivo

Lung Cancer - Researchers establish patient-like SCID mouse model

Lung Tumors - Percutaneous radiofrequency ablation of lung tumors shown safe and effective

Lymphangiogenesis - VEGF-C may be involved in tumor cell dissemination

Lymphoma - Adding rituximab to chemotherapy does not influence response in older patients

Lymphoma - Foundation to provide $12.8 million for mantle cell research

Lymphoma - The diagnosis of primary lymphoma of bone does not confer improved prognosis

MALT Lymphoma - Stability and subcellular localization of API2-MALT1 chimeric protein

Macular Degeneration - Mutations at CDH3 may cause hypotrichosis with juvenile macular dystrophy

Malignant Lymphoma - FDG-PET is superior to Ga-67 scan in the staging of malignant lymphoma

Melanoma - Cyr61 is a hypoxia-inducible cytokine in metastatic melanoma cells

Melanoma - Intracellular regulation of evodiamine-induced A375-S2 cell death

Metastasis - Prospective quality-of-life research investigated in bony metastatic disease

Metastatic Bone Disease - Endoprosthetic reconstruction useful alternative for certain bone metastases

Metastatic Bone Disease - PET effective in detecting of osseous metastasis from several malignancies

Metastatic Cancer - Combidex useful in detecting the spread of cancer to lymph nodes

Metastatic Disease - Internal stabilization of impending pathologic fractures appropriate for most

Metastatic Solid Tumors - Phase I study evaluates advanced solid tumor therapy

Multiple Myeloma - Alterations of RAS signaling are critical in multiple myeloma pathogenesis

Multiple Myeloma - High-dose chemotherapy more beneficial for MM patients with high-risk features

Multiple Myeloma - Imatinib mesylate suppresses MM tumor cell proliferation in vitro

Multiple Myeloma - MM antigen HM1.24 loaded in adeno-associated virus produces anticancer T cells

Multiple Myeloma - Unrelated stem-cell transplantation can be effective for MM patients

Muscular Dystrophy - NaPro awarded phase I SBIR grant for research on DMD

Musculoskeletal Tumors - Materials presented at tumor society meeting may not be scientifically valid

Mutagenesis - Hypoxia-inducible factor-1 alpha polymorphisms modulate tumor progression

Myelodysplastic Syndrome - New drug treats anemia in patients with MDS

Myeloid Tumors - Mutational analysis of ST7 do not commonly contribute to human myeloid tumors

Nasopharyngeal Carcinoma - NPC Spanish patients positive for EBV express p53 in late tumor stage

Neuroendocrine tumors - Neuroendocrine tumors of the appendix are easily curable by appendectomy

Neuroscience - Therapy containing a multiple of death ligands targets brain tumor cells

Nicotine Addiction - Some varieties of smokeless tobacco "90% less hazardous than cigarette smoking"

Non-Hodgkin Lymphoma - Company submits CMC section of new drug application for Onco TCS

Oncogene Activation - Poleta is important in inducing hypermutability in codon 12

Oncology - An anticancer compound found in garlic induces apoptosis by binding tubulin

Oncology - Angiostatin gene therapy doesn't stop human neuroblastoma xenografts

Oncology - Cancer distress screening methods recommended

Oncology - Choline-containing compounds may not be markers for apoptotic death

Oncology - Cytokine signals cooperate in the presence of retinoic acid receptor alpha

Oncology - Myostatin inhibition causes human rhabdomyosarcoma cells to differentiate

Oncology - The dynamics of tumor vascularity change upon treatment with VEGF inhibitor

Osteosarcoma - Noninvasive expandable prosthesis promising for skeletally immature children

Ovarian Cancer - Autoantibody to epithelial cell adhesion molecule is higher in ovarian cancer

Ovarian Cancer - The prognostic value of HPV detection may be underestimated

Papillary Thyroid Carcinoma - BRAF mutations are restricted to papillary carcinomas

Pathologic Fractures - PMMA may stabilize bone and deliver antineoplastic and antiresorptive agents

Pediatric Cancer - Researchers investigate alteration of the Axin gene in pediatric neoplasms

Pediatric Cancer - Topical imiquimod cream stops vascular tumor growth in study models

Personnel - Goyjer named executive director of breast cancer research fund

Pituitary Adenomas - Stereotactic radiosurgery effective for previously irradiated pituitary adenomas

Pituitary Tumors - A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells

Preventive Medicine - NSAIDs inhibit angiogenesis by suppressing molecular switches

Prostate Cancer - An inhibitor of the enzyme MMP-9 attenuates angiogenesis and tumorigenicity

Prostate Cancer - Complementary medicine use high for prostate cancer

Prostate Cancer - Eligard receives marketing authorization in Germany

Prostate Cancer - FDA grants fast track status for MLN2704

Prostate Cancer - GSTP1 QMSP improves sensitivity of histologic review of random needle biopsies

Prostate Cancer - Male lumpectomy is a promising new treatment

Prostate Cancer - NFkappaB is a pivotal transcription factor in prostate cancer metastasis to bone

Prostate Cancer - New partner sought to commercialize Trelstar

Prostate Cancer - Requirements for proton therapy of prostate cancer outlined

Prostate Cancer - Spectroscopy, new prostate cancer markers may improve data interpretation

Prostate Cancer - Unconventional therapy for prostate cancer may do more harm than good

Radiation Exposure -  Chelidonium majus CM-Ala may protect against radiation exposure

Radiation Exposure - Bacteria related to Sulfobacillus spp. can survive radiation from uranium

Radiation Therapy - IMPAC to help develop DICOM-RT linear accelerator interface

Reconstructive Surgery - Intervention can ward off reconstructive failure in metastatic disease of tibia

Renal Cell Carcinoma - Epidermal growth factor receptor blockade may supplement cytotoxic chemotherapy

Sarcoma - Competing-risks nomogram estimates probability of sarcoma-specific death

Sickle Cell Anemia - Anticancer compound may offer new treatment for sickle cell anemia

Soft-Tissue Sarcoma - Immediate, postoperative brachytherapy is safe for microvascular anastomosis

Spinal Cord Tumors - Radiotherapy only benefits partially resected spinal ependymomas

Spinal Metastases - Evaluation and treatment of metastatic disease of the spine under review

Squamous Cell Carcinoma - Human papillomavirus type 16 is prevalent in adult tonsil, not oral cavity SCC

Surgery - Video-assisted thoracic surgery has high initial cost

Tissue Analysis - MALDI-MS allows direct analysis of drug candidates in tissue

Tobacco Use - Family-based research is required to investigate factors in tobacco dependency

Transplant Medicine - Transplant-associated porokeratosis can lead to squamous cell carcinoma

Trends - Report: Looking for the pharmaceutical-biotechnology alliance creates a win-win

Tumor Inhibition - A gap junction-independent tumor-suppressing effect of connexin 43 reported

Tumor Markers - Pancreatic endocrine neoplasms are more likely to have p27 if metastasizing

Tumorigenesis - Preneoplastic mouse cells require osteopontin for malignant transformation

Tumors Lysis Syndrome - IV allopurinol and rasburicase offer flexibility in managing TLS

Vector Development - Antibody directed against c-Met improves gene delivery to liver cancer cells

Vertebral Collapse - Vertebroplasty, kyphoplasty relief pain fast in osteolytic vertebral collapse