Anticancer Compounds

Triptonide biotransformation by Aspergillus niger yields less active drugs

Published in Cancer Weekly, December 30th, 2003

Triptonide biotransformation by Aspergillus niger yields less active drugs.

"The diterpenoid triepoxides are the major active constituents of Tripterygium wilfordii, with potent antitumor and immune activities. But the strong toxicity of these compounds has restricted their application to a great extent," scientists writing in the journal Planta Medica report.

"In order to find more effective compounds with less toxicity, structural modifications of triptonide (1) by Aspergillus niger (AS 3.739) were investigated: four biotransformed products were obtained.

"Based on their chemical and spectral data,...

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Source: Cancer Weekly (2003-12-30)

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