Biological Therapy

The Th1/Tc1 circuit can produce tumor-specific CTL, even though Th2 can kill

Published in Cancer Weekly, December 30th, 2003

The Th1/Tc1 cell therapy circuit produces tumor-specific CTL producing IFNgamma, even though Th2 cell therapy can kill and produce IL-4.

"Th1 and Th2 cells obtained from OVA-specific T cell receptor transgenic mice completely eradicated the tumor mass when transferred into mice bearing A20-OVA tumor cells expressing OVA as a model tumor antigen," researchers in Japan report.

"To elucidate the role of Tc1 or Tc2 cells during tumor eradication by Th1 or Th2 cell therapy, spleen cells obtained from mice cured of tumor by the therapy were restimulated with the model tumor antigen (OVA) for 4 days. Spleen cells obtained from mice cured by Th1-cell therapy...

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Source: Cancer Weekly (2003-12-30)

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