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Breast Cancer

New data underlines Modrenal's genetic mechanism of action in breast cancer

Published in Cancer Weekly, December 30th, 2003

Bioenvision, Inc., (BIV) has presented new data underlining the ability of its lead breast cancer treatment, Modrenal (trilostane), to suppress the activity of estrogen at two groups of genes involved in breast cancer growth.

The research from Queen Mary, University Of London, and presented for the first time at the 26th San Antonio (Texas) Breast Cancer Symposium, helps to explain reported clinical benefit rates of over 50% and differentiates Modrenal's mechanism of action from existing therapies, such as tamoxifen and the aromatase inhibitors.

In hormone sensitive breast cancer, estrogen affects tumor growth through two main pathways. The preferred...

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