Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . January 6th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Colorectal Cancer - Calcium and vitamin D collaborate to reduce cancer risk
Bone Marrow Transplantation - Repifermin reduces the severity of graft-versus-host-disease
Glaucoma - Proprietary Factor 5A1 shows promise for controlling glaucoma
Graft-versus-Host Disease - Agreement signed with NIH to develop Theralux device
Gynecological Cancer - Proteomics is the newest, most promising direction for gynecologic cancer
Head and Neck Cancer - Met Y1253D mutations prevail in many patients with radioresistant cancers
Head and Neck Cancer - Patients with throat cancer should have endoscopic ultrasound examination
Helicobacter Pylori - Reinfection with new H. pylori strains is common after antibiotic therapy
Hematuria - Multidetector row CT urography may permit evaluation of hematuria
Hepatitis - A key hepatitis C virus protein modulates apoptosis in liver cells
Herpes Simplex 2 - New or old Pap smears can be destained and used to test for HSV-2 viral DNA
Herpes Simplex Virus - Immunotherapy company provides update on late-stage adjuvant programs
Brain Cancer - Bone marrow-derived endothelial progenitor cells are marginal to gliomas
Hodgkin Disease - Results of phase I/II clinical study of MDX-060, targeting CD30, reported
Ileoinguinal Tumors - Ileoinguinal tumors should be considered for primary excision, reconstruction
Imaging - Whole-body PET/CT scan appears useful for determining tumor stage
Immunology - John Weinstein, MD, PhD, appointed to scientific advisory board
Immunosuppression Risk - Cutaneous extramedullary plasmacytoma can occur following heart transplant
Kidney Cancer - Research shows cancer can be diagnosed in urine
Kidney Diagnostics - Retinol in urine may indicate renal dysfunction in multiple myeloma patients
Leukemia - Abstracts report on drug-induced apoptosis in cultured cancer cells
Leukemia - Clofarabine active in combination with Ara-C for adult acute myeloid leukemia
Leukemia - Data from numerous studies cite activity of Nipent combination therapy
Brain Tumors - A delivery system for targeting anticancer drugs to the brain developed
Leukemia - Data reported in trials of heat shock protein-based cancer vaccines
Leukemia - Drug prolongs lives of chronic lymphocytic leukemia patients
Leukemia - Initial leukemia diagnosis should include eye exam
Leukemia - Interim data reported from phase II trial of GVAX vaccine
Leukemia - Nelarabine works in aggressive, resistant forms of childhood T-cell malignancies
Leukemia - Qualitative methods in environmental health research
Leukemia - Rituximab leads to substantial but transient down-modulation of CD20 expression
Liver Cancer - Preclinical results reported on the use of ThermoDox
Liver Cancer - Transgastric fine-needle biopsies sample high risk patients for malignancy
Lung Cancer - COX17 is a therapeutic target for the treatment of non-small cell lung cancer
Breast Cancer - Altered cyclin E protein linked to genetic instability, endocrine resistance
Lung Cancer - Randomized evidence in chemotherapeutic regimens for some NSCLC biased
Lung Cancer - Risk model with intermediate endpoints needed for new lung cancer chemo studies
Lung Cancer - Surgery can now successfully treat lung cancers once deemed inoperable
Lymphography - Old lymphography technique retains its usefulness
Lymphoma - Radiographic-MR imaging depicts soft-tissue metastasis in primary bone lymphoma
Malignant Hematopoiesis - RTK classes, known to be expressed on normal hematopoietic tissue, summarized
Market Analysis - Adjunctive imaging technologies help with early detection of breast cancer
Market Analysis - Positron emission tomography industry faces reduction in growth
Medical Research - Developments in cancer, heart disease lead year's medical breakthroughs
Medulloblastoma - Continuing research should improve, may achieve cure of common neoplasms
Breast Cancer - Battery-powered gamma detection probe available for lymph node mapping
Melanoma - Fibroblasts may control melanoma cell invasion after start of tumor progression
Minimal Residual Disease - Campath (alemtuzumab) achieves significant responses, molecular remissions
Mitochondrial Disease - Drosophila model of human mitochondrial disease developed
Multiple Myeloma - Data from SGN-30 clinical trials shows antitumor activity
Multiple Myeloma - Data suggests Quadramet provides pain relief for certain cancer patients
Multiple Myeloma - New data announced on the effects of telomerase inhibitor drugs
Multiple Myeloma - Opportunities to get more patients into clinical trials being missed
Multiple Myeloma - Promising clinical data on Actimid presented at ASH
Multiple Myeloma - Velcade demonstrates activity in previously untreated multiple myeloma
Breast Cancer - Chemotherapy advance reported for women with node-positive early breast cancer
Musculoskeletal Sarcoidosis - MRI reveals a range of musculoskeletal abnormalities in sarcoidosis patients
Myelodysplastic Syndromes - Additional data presented on Revimid at hematology meeting
Nausea - Antiemetic regimen improved control of chemotherapy-induced nausea, vomiting
Neuroblastoma - Risk of second malignant neoplasms increased after childhood neuroblastoma
Neuroscience - NF2 gene overexpression thwarts schwannoma cell growth
Nicotine Addiction - Most popular snuff brands also have big nicotine doses
Non-Hodgkin Lymphoma - Data presented from study of Rituxan as front-line and maintenance therapy
Non-Hodgkin Lymphoma - MyVax Personalized Immunotherapy shows promise in mantle cell lymphoma
Non-Hodgkin Lymphoma - Phase III trial of non-Hodgkin lymphoma therapy reaches endpoint early
Non-Hodgkin Lymphoma - Pixantrone induces major tumor response in relapsed aggressive lymphoma
Breast Cancer - Data from Theratope Vaccine trial presented
Oncology - Antisense suppression of proapoptosis genes limits melanoma angiogenesis
Oncology - Breast cancer coexpresses tumor specific VEGF-A and VEGFR2/KDR protein
Oncology - Interventional strategies that decreasing rate of clonal expansion preferred
Oral Mucositis - Phase III data show that Palifermin improves oral mucositis in cancer patients
Ovarian Cancer - Women at high risk for ovarian cancer aren't getting the care they need
Pancreatic Cancer - A phase II trial investigates glufosfamide for advanced pancreatic cancer
Pancreatic Cancer - RNA interference of focal adhesion kinase makes cancer chemosensitive
Paratesticular Cancer - CT, MRI findings helpful in evaluating and narrowing paratesticular neoplasms
Patents - Additional patent granted on cartridge technology for DNA analysis
Pediatric Cancer - Thalidomide antagonizes neuroblastoma vessel growth
Breast Cancer - Fewer than half of patients with early-stage disease get full chemotherapy dose
Personnel - Karen Auditore-Hargreaves named president of cancer therapeutics company
Policy - Americans want more money directed to cancer research
Prostate Cancer - Alpha-methylacyl-coenzyme A racemase may be an important prostate cancer marker
Prostate Cancer - Androgen receptor involved in resistance to drugs
Prostate Cancer - Biology of prostate-specific antigen reviewed
Prostate Cancer - Black men should be screened for prostate cancer at younger age
Prostate Cancer - Heavy metal-metabolizing proteins involved in human prostate homeostasis
Prostate Cancer - Improved tools for analyzing prostate cancer genes are needed
Prostate Cancer - New targets for therapy in prostate cancer discussed
Prostate Cancer - Older patients may face age bias
Breast Cancer - Mammograms don't reach all communities equally
Prostate Cancer - Phase II study shows citrus fruit nutrient combats prostate cancer
Prostate Cancer - Researchers identify molecular cause of drug-resistant disease
Prostate Cancer - Risk of prostate cancer is associated with family history of disease
Prostate Cancer - Signaling pathway of prostate cancer profiled using protein arrays
Prostate Cancer - Vitamin D should be a priority for men of all ages
Proteomics - Protein microarrays are effective molecular profiling technologies
Radiosurgery - Growth of extracranial radiosurgery highlighted at CyberKnife Users' Meeting
Rectal Cancer - New developments in radiology and oncology may further increase patient survival
Rectal Cancer - Preliminary results of laparoscopic resection for rectal cancer are promising
Breast Cancer - Oral drug shows promise for prevention of ER-negative disease in mouse model
Rectal Cancer - Rectal cancer outcome dependent on diagnostic, oncologic, technical principles
Renal Lesions - Color Doppler sonography is a standard method renal artery stenosis screening
Renal Tumor - Multiple roles of the tuberous sclerosis complex genes reviewed
Research Collaborations - Alliance formed for oncology therapeutics development
Sarcoma - Leg lengthening should be offered only to long-term sarcoma survivors
Small Bowel Cancer - Small intestinal carcinoid tumors have a favorable prognosis
Smoking Cessation - Financial payoff for quitting smoking may take years
Solid Tumors - Vascular targeting agents granted European patent
Stem-Cell Biology - Researchers get stem cells to form blood vessels
Stem-Cell Transplantation - New stem-cell transplantation drug addresses unmet need in cancer patients
Radiology - Cancer's love-hate relationship with proteins offers new treatment window
Breast Cancer - Positive Abraxane phase III data released
Stress Proteins - Heat shock proteins 70 and 40 are upregulated in many gastric cancer tissues
Systemic Lupus Erythematosus - Company inks autoimmune-therapy agreement with the University of Michigan
T-Cell Malignancies - Results of BCX-1777 phase I study reviewed
Transforming Growth Factor - Targeting of TGF-beta may control cell growth, apoptosis in cancer cells
Tumor Growth - New eco-evolutionary model of tumor dynamics described
Tumor Suppressor Gene - Haploinsufficient genes requiring inactivation of only one allele
Tumors - Data on next-generation VEGF cancer agent presented at ASH
Tumors - Model for the early growth of DCIS of the breast is formulated
Ultrasonography - Invasive ductal carcinomas appear larger on viscoelastic scan than B-mode image
Uterine Enlargement - MR imaging allows specific diagnosis of diffusely enlarged uterus
Breast Cancer - Positive data reported on phase II breast tumor cell proliferation study
Vector Development - Micelle formation is key to how chlorpromazine augments retroviral transduction
Venous Thromboembolism - Guideliness on venous thromboembolism prophylaxis reconsidered
Virology - De novo methylation patterns are common to papillomavirus DNA
Women's Health - The global cancer burden in women appeared to be increasing quickly
Yellow Fever - BLA filed for Arilvax vaccine
Breast Cancer - Post-tamoxifen use of Femara reduces risk of breast cancer recurrence by 43%
Breast Cancer - Randomized trial examines second-line endocrine therapy in advanced breast cancer
Breast Cancer - Researchers develop a mathematical modeling of comedo DCIS of the breast
Breast Cancer - Residential magnetic field exposure does not increase risk of breast cancer
Breast Cancer - SAFB1 and SAFB2 may be novel breast tumor suppressor genes
Breast Cancer - Shc proteins are prognostic markers for primary breast cancer
Breast Cancer - Short-term postmenopausal hormone therapy does not measurably increase breast cancer risk
Breast Cancer - Some patients may benefit from endocrine therapy alone
Bone Cancer - Bisphosphonate suppress growth and induces apoptosis in cancer cells in culture
Breast Cancer - Study data indicate promise for investigational compound GW572016
Breast Cancer - Study supports tailoring adjuvant therapy for early-stage disease
Breast Cancer - Study to provide more data on targeted 5-day radiotherapy for DCIS patients
Breast Cancer - Tailored dosage of chemotherapy is effective treatment, study shows
Breast Cancer - Urokinase-type plasminogen activator receptor marks metastatic breast cancer
Cancer Anorexia - Nutrition counseling, drug therapy recommended for anorectic cancer patients
Cancer Cell Migration - Requirement discussed for Arf6 in cell adhesion, migration, cancer cell invasion
Cancer Detection - Company receives CE Mark for Nipple Endoscope
Cancer Epidemiology - EUROCARE-3 publishes new childhood cancer survival figures
Cancer Market - Non-small cell lung cancer drug market to exceed $4.1 billion in 2012
Cancer Therapy - Angiotensin II receptor blockers staunch prostate cancer growth
Cancer Metastasis - Homocysteine thiolactone is a proangiogenic agent
Cancer Pain - Company reports on phase II meeting with FDA on Oravescent Fentanyl
Cancer Pain - Differential documentation of pain may be noted when hospice is involved
Cancer Pain - The effect of donepezil in patients receiving opioids for cancer pain
Cancer Prevention - Organosulfer compounds stop liver cancer invasion, migration, and angiogenesis
Cancer Prognosis - Cyclooxygenase-2 is a prognostic indicator of oral squamous cell carcinoma
Cancer Research - Teratomas from stem cells provide a platform for studying cancer mechanisms
Cancer Screening - Information interventions may help people make screening decisions
Cancer Symptoms - Modified Rotterdam Symptom Checklist is reliable, valid for cancer patient use
Cancer Therapies - New way to lock DNA-slicing enzyme onto chromosomes could lead to novel drugs
Oncology - Many factors affect how oncolytic adenoviruses transfect tumors
Cancer Therapy - Data: LPAAT-beta has potential use in myeloid and lymphoid malignancies
Cancer Therapy - INEX releases Onco TCS data from three clinical trials
Cancer Therapy - Inhibiting DNA replication-initiation protein induces apoptosis
Cancer Therapy - Novacea licenses anticancer product candidate
Cancer Therapy - P-glycoprotein and Mrp1 protect bone marrow from vincristine-induced toxicity
Cancer Therapy - Researchers analyze model of a virus that replicates selectively in tumor cells
Cancer Therapy - Study: Multiple mechanisms of action make INGN 241 a promising approach
Cancer Therapy - VGA1155 inhibits vascular endothelial growth factor binding
Cancer Vaccine - Tumor growth inhibited by vaccination with Her-2/neu peptides
Cancer Vaccine - Vaccines for leukemia therapy reviewed
Radiotherapy - Microbeams point to future of radiotherapy
Carcinogenesis - Multiple mechanisms contribute to the carcinogenicity of cadmium
Carotid Artery - Delayed complications of endovascular stenting for carotid blowout examined
Cell Biology - Autophagy active in tumor suppression
Cell Biology - Functions of p53 equally important in halting for cancer cell growth
Cell Metabolism - The immunomodulator FTY720 bars VEGF-induced vascular permeability
Cell Signaling - Nomadic outposts of transplanted stem cells tracked
Cervical Cancer - Educating women about disease link to smoking persuades more to quit
Cervical Cancer - Eighty-one percent of surveyed women want noninvasive cervical cancer test over Pap test
Chemotherapy - Additional patent issued for Tocosol Paclitaxel cancer drug
Chest Wall Tumors - CT, MRI help in delineating location, extent of chest wall tumors
Acute Myeloid Leukemia - Genasense plus chemo demonstrates enhanced activity for older AML patients
Chronic Myelogenous Leukemia - Abnormal bone marrow angiogenesis persists after stem cell transplantation
Collaborations - Deal signed for solid-tumor cancer treatment development
Colon Cancer - A3 adenosine receptor agonist inhibits colon cancer growth
Colon Cancer - Activation of PPAR gamma in colon tumor cell lines
Colon Cancer - Dendritic cell vaccine to be used in trial for new cancer treatment
Colon Cancer - Total energy and macronutrients associated with colon cancer risk
Colon Cancer Screening - Risk factors determine need for colonoscopy
Colorectal Cancer - 15-Hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer
Colorectal Cancer - Knudson's theory can explain diverse experimental situations
Colorectal Cancer - Phase II clinical trials of KOS-862 initiated
Antisense Technology - Vectosomes improve the delivery of antisense oligonucleotides
Colorectal Cancer - Study projects colorectal cancer drug sales to reach $2.1B in 2012
Diagnostic Medicine - Organotypic raft cultures typify spectral analysis of in vivo tissues
Drug Delivery - Preclinical data on microbubble drug delivery reported
Drug Development - Circadian rhythms reveal when antiangiogenic therapy should be administered
Ebola Virus - NIH begins human Ebola vaccine trial using Biojector 2000
Endometrial Cancer - A systematic and practical approach to the endometrial biopsy outlined
Environmental Health Research - Compounding issues become more complex with introduction of new bio-technologies
Enzymology - When the Src family of kinases are shut down, angiogenesis ceases
Esophageal Cancer - An invagination technique treats esophagogastric end-to-end anastomoses
Finance - Cancer therapy maker announces $5.62 per share loss for third quarter
Biological Rhythms - Change in biological rhythms may cause early deaths from premature aging, cancer
Finance - Cancer vaccine company reports $10M net loss; provides clinical update
Finance - Diagnostics company receives $3.5 million private placement
Finance - Private placement to advance skeletal targeted radiotherapy phase III trial
Fundus - Sophisticated new camera systems are available for documenting ocular fundus
Gastroenterology - Phase I study evaluates S-1 combined with cisplatin for metastatic GI cancer
Gastrointestinal Motility - Positive ITAX phase II results reported
Gene Dectection - Lung cancer and fibroblast cocultures reveal genes linked to cancer progression
Gene Expression - Optimized adenovirus directs genes to designated cells
Genomics - Human MutY genetic mutations detected in cancer
Geriatrics - Persons 80 and older make up the largest growing surgical population in U.S.
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