Insulin-Like Growth Factor

IIp45 antagonizes IGFBP-2 stimulation of glioma cell invasion

Published in Cancer Weekly, January 13th, 2004

IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion.

According to a study from the United States, "Our previous studies have shown that insulin-like growth factor binding protein 2 (IGFBP-2) is frequently overexpressed in the highly invasive glioblastoma multiforme (GBM). By using a yeast two-hybrid system, we identified a gene, invasion inhibitory protein 45 (IIp45), whose protein product bound to IGFBP-2 through the thyroglobulin-RGD region of the C terminus of IGFBP-2. The IIp45 gene is located on chromosome 1p36 and has nine exons."

"The IIp45 protein has three...

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Source: Cancer Weekly (2004-01-13)

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