Breast Cancer

TOP2A aberration testing may help identify targeted breast cancer therapies

Published in Cancer Weekly, January 13th, 2004

Testing for TOP2A aberrations may be useful in the search for individually tailored treatment regimes for breast cancer, researchers report.

According to recent research from Norway, "The TOP2A gene is located on chromosome 17 close to the HER-2 gene

"It encodes an enzyme involved in the regulation of cell proliferation. Using fluorescence in situ hybridization (FISH), we have examined fine needle aspiration smears from 42 cases of breast carcinoma with probes for TOP2A, HER-2 and chromosome 17," wrote A.M. Bofin and colleagues, Norwegian University of Science & Technology, Medical Faculty.

"We found that amplification of TOP2A is...

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Source: Cancer Weekly (2004-01-13)

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