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Hepatocarcinoma

Human hepatocellular carcinoma-associated HCAP1 gene may be related to cancer

Published in Cancer Weekly, January 27th, 2004

Research suggests that the HCAPI-M variant of HCAPI has a reduced inhibitory effect on hepatocarcinoma cell growth.

According to a study from the People's Republic of China, "We have cloned a cDNA from chromosome band 17p13.3, designated as HCAPI (HCC-associated protein 1, originally named HC56). Database searches revealed that HCAPI shares most of its open reading frame with GEMIN4."

"Single nucleotide polymorphism (SNP) screening revealed a high incidence of SNP in the coding region of HCAPI (12 SNP sites). A collection of 140 controls and 22 cases from the Qidong area was genotyped at 6 SNP sites," wrote D.F. Wan and colleagues, Jiao Tong...

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