Apoptosis
Fas apoptosis activation involves microaggregates if by anti-Fas Ab, not FasL
Published in Cancer Weekly, January 27th, 2004
According to published research from France, "the 45 kDa Fas or CD95 receptor triggers apoptosis via the caspase cascade when stimulated by its ligand FaA or by agonistic antibodies.
"Activated Fas receptors seem to oligomerize very early into SDS-stable and reducing agent-resistant microaggregates of 200-250 kDa on SDS-PAGE. However, these microaggregates have so far only been reported using agonistic anti-Fas Abs, and no results have been reported using FasL."
"Here, we demonstrate that the microaggregates do...
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Source: Cancer Weekly (2004-01-27)
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