Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . February 3rd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Metastasis - Wound-healing genes influence cancer progression
Anticancer Therapy - Cisplatin does not directly effect mitochondrial oxygen consumption
Laryngeal Cancer - Genomic changes in premalignant laryngeal lesions could indicate cancer risk
Leukemia - Common clonal origin seen in twins with leukemia
Leukemia - Malignant stem cells express high levels of FGFR-3
Leukemia Diagnostics - LightCycler, TaqMan tests equally suitable for pediatric MRD measurement
Leukemia Diagnostics - MRP3 linked to drug resistance in pediatric ALL
Leukemia Diagnostics - ZAP-70 expression is a prognostic factor in CLL patients
Liver Cancer - IND filed to initiate human trials of ThermoDox
Lung Cancer - Questionnaires can identify lung cancer patients needing intervention
Biomarker - CD105/endoglin is a marker for endometrial cancer angiogenesis
Melanoma - B. pertussis toxin induces T-cell responses against melanoma
Melanoma - G protein-coupled receptors could participate in regulating metastatic melanoma
Melanoma - Melanoma progression is related to a mutation in protein phosphatase type 2A
Melanoma - Tanning devices - fast track to skin cancer?
Mergers and Acquisitions - Biopharma adds three clinical-stage oncology drug candidates to its pipeline
Myelodysplastic Syndrome - Role of FLIP isoforms in apoptosis elucidated
Neonatal Tumors - An international working group reports on the epidemiology of neonatal tumors
Nicotine Addiction - Report gives failing grades to state of Missouri
Bladder Cancer - Karyometry can detect abnormalities in normal urothelium near carcinoma
Non-Hodgkin Lymphoma - Update provided on program evaluating Proleukin interleukin-2
Non-Small Cell Lung Cancer - NSCLC growth in mouse xenografts, in vitro cannot predict patient outcomes
Oligodendrogliomas - Different genetic pathways involved in pediatric vs. adult ogliodendrogliomas
Oncogenesis - Hepatitis B virus DNA fluctuations mark cell injury and cancer potential
Oncology - BAG-1 uses a variety of pathways to generate chemoresistance
Oral Lesions - Tobacco chewing can lead to multiple oral premalignant lesions
Osteogenic Sarcoma - Zoledronic acid induces apoptosis of human osteogenic sarcoma cells in vitro
Ovarian Cancer - Administering topotecan weekly shows promise in the management of ovarian cancer
Ovarian Cancer - New treatments are needed to overcome high relapse rates of ovarian cancer
Brain Tumors - A 10-degree reverse Trendelenburg position can reduce pressure during craniotomy
Ovarian Cancer - Researchers analyze social concerns of women with ovarian cancer
Pancreatic Cancer - Apoptosis in pancreatic cancer cells is induced by arsenic trioxide
Pancreatic Cancer - Quinone oxidoreductase induces growth inhibition of pancreatic cancer
Patents - U.S. patent granted for treatment of human papillomavirus infections
Patents - Vaccine company gets broad patent coverage for its core technology platform
Penile Carcinoma - Imiquimod 5% cream is effective in intraepithelial penile carcinoma
Personnel - Biotechnology company announces new member to board of directors
Personnel - Hershberg promoted to senior VP, chief medical office at oncology company
Pituitary Tumors - Chronic ovarian hyperstimulation may precede a subset of pituitary adenomas
Postoperative Pain - Results of the postoperative pain management project are described
Brain Tumors - Gliadel prolongs survival and time to relapse in some glioma patients
Prostate Cancer - An organoselenium compound induces apoptosis in prostate cancer cell lines
Prostate Cancer - Atrigel formulation advances into additional human clinical testing
Prostate Cancer - CYP3A4 and CYP3A5 genotypes, haplotypes, are related to risk of prostate cancer
Prostate Cancer - Dynamic contrast-enhanced MRI is sensitive in visualizing prostate cancer
Prostate Cancer - Each prostate biopsy core should be assigned a separate Gleason score
Prostate Cancer - High-dose rate brachytherapy has advantages for prostate cancer treatment
Prostate Cancer - Oncology biopharmaceutical company raises $35 million in series C financing
Prostate Cancer - Trioxifene (LY133314) can prolong survival in a PAIII rat prostate cancer model
Radiation Therapy - 3-D cone-beam imaging system receives FDA clearance
Brain Tumors - Idarubicin unlikely to be used for treating primary CNS tumors
Radiation Therapy - FDA issues 510k clearance for Trilogy system
Rectal Cancer - Survival of rectal cancer patients over age 75 has improved
Renal Cancer - IGF2, a potent growth factor, may play a role in renal clear cell sarcoma
Severe Combined Immune Deficiency - Unusual leukemia caused by rare combination of genes
Skin Cancer - Selenium supplementation is not effective against skin cancer
Skin Cancer - Skin photographs may help patients detect new or changed moles
Stem-Cell Research - Acute myeloid leukemia fusion proteins deregulate maintenance and repair genes
Stem-Cell Transplantation - High-level cryopreservation of mobilized PBSC feasible without programmed freezer
Tumor Suppression - A recombinant fragment of thrombospondin-2 halts VEGF-induced tumor growth
Tumor-Activated Prodrugs - Cantuzumab mertansine and huN901-DM1 advance to proof-of-concept studies
Breast Cancer - Anthracyclines activate antiapoptotic phosphorylation in breast cancer
Tumorigenesis - Progressive alterations in global and GC-rich DNA methylation help tumorigenesis
Venous Thromboembolism - Study reviews issues of DVT associated with central venous catheters
Virology - Longer interferon regimens might clear hepatitis D virus
Breast Cancer - Beta3 integrin expression can lead to increased tumor cell aggressiveness
Breast Cancer - Breast cancer resistance protein is a MTX and MTX-polyglutamate transporter
Breast Cancer - Dragon-boat racing helps heal cancer survivors in Singapore
Prostate Cancer - Hormone therapy leads to high rates of osteoporosis in men
Breast Cancer - Increased breast cancer risk may be related to the HLA class III subregion
Breast Cancer - NSAIDs may have chemopreventive effect against breast cancer
Breast Cancer - Nematode finding could shed light on BRCA1-involved cancers
Breast Cancer - Noninvasive treatment technique uses space-based technology
Breast Cancer - P1 homozygosity may be a potential risk factor in breast carcinogenesis
Breast Cancer - Pooled analysis of LOH in breast cancer finds many nonreproducible results
Breast Cancer - Researchers study familial and early onset breast cancer in African Americans
Breast Cancer - Risk differs among specific ethnic subgroups of South Asian women in U.K.
Breast Cancer - Sequential drugs followed by TRAIL may be a new therapeutic approach for cancer
Breast Cancer - Steroid hormone-resistant breast cancer can be sensitive to growth factors
Breast Cancer - Side effects make physicians, patients reluctant to use tamoxifen for DCIS
Breast Cancer - Ultrasound detects many microcalcifications in comedo-type intraductal carcinoma
Breast Cancer - Underarm cosmetics with estrogen may contribute to breast cancer
Breast and Ovarian Cancer - Many BRCA1 and BRCA2 genes mutations are unique to Spain
Breast and Prostate Cancer - Kahalalide F preferentially induces cell death via oncosis in tumor cells
Cancer Metastases - Liver metastases from unknown primary site are shown by MR imaging
Cancer Metastases - Researchers use and advocate SRS3xGado scans for cerebral radiosurgery
Cancer Risk Factor - Type 1 diabetes increases cancer risk
Cancer Therapy - Canstatin-N fragment stops endothelial cell proliferation and tumor growth
Cancer Therapy - Computerized clinical reminders are helpful for physician prescribing behavior
Cancer Therapy - Data shows CF101 to be effective in restraining growth of certain cancers
Gene Suppression - Telomerase is a major regulator of leukemia cell growth
Cancer Therapy - Enrollment complete for phase II clinical study in non-Hodgkin lymphoma
Cancer Therapy - FLAG±Ida suitable for induction chemo in high-risk leukemia, MDS patients
Cancer Therapy - Fusion proteins steer tumor necrosis factor-alpha to tumor blood vessels
Cancer Therapy - Granulocyte colony-stimulating factor reduces complications in elderly patients
Cancer Therapy - Standard chemotherapies target specific sectors of the angiogenic cascade
Cancer Vaccine - Tumor cells plus adjuvant induced immunity against hepatoma
Carcinogens - Arsenic accumulates in mouse organs after repeated oral exposure
Carcinogens - Arsenite boosts the expression of proliferation factors in prostate cancer cells
Carcinogens - Riddelline is toxic and carcinogenic in rats and mice
Cell Death - Evidence identifies the role of potassium homeostasis in apoptosis
Head and Neck Cancer - Novel technique may help detect certain squamous cell cancers
Cell Signaling - Jellyfish proteins help researchers see tumor suppression, live
Cervical Cancer - Kaiser to routinely offer new DNA testing for cervical cancer in northern California
Cervical Cancer - Screening strategies of cervical cancer high-risk region compared
Chemotherapy - IND filed for phase I/II trial of MagneTarg system to deliver mitomycin C
Chemotherapy - Keynote address on Xyotax delivered at polymer therapeutics meeting
Chemotherapy - Tocosol Paclitaxel anticancer drug receives third patent
Clinical Trial - ImClone gets $5 million payment relating to approval of ERBITUX in Switzerland
Collaborations - Alliance with M.D. Anderson to develop new cancer drugs announced
Collaborations - Biotech enters partnership with Institute for Cancer Prevention to fight cancer
Collaborations - Myriad Genetics agreement to include pharmacogenetics
Hepatic Cancer - Syndecan-1 may be a prognostic marker in intrahepatic cholangiocarcinoma
Colon Cancer - Disease specific, quality-of-life questionnaires may help cancer patients
Colon Cancer - Eloxatin becomes a cornerstone therapy in Europe
Colon Cancer - Silibinin may be useful in colon cancer prevention and intervention
Colon Cancer - U.K. diagnostic services will not cope with national bowel cancer screening role
Colorectal Cancer - Clinical trial initiated for colorectal cancer antitumor compound
Colorectal Cancer - Company responds to reports of phase II VELCADE colorectal trial closure
Colorectal Cancer - Gamma tocopherol may be a potent colorectal cancer chemopreventive agent
Colorectal Cancer - Health plans can improve colorectal cancer screening rates
Crohn Disease - Company announces reimbursement for capsule endoscopy primary procedure
Abortion - Minnesota health department changes language on website
Developmental Biology - Regulating folate receptors during folate deficiency
End-of-Life Care - Study suggests more cancer patients receiving aggressive care at end of life
Environmental Health - Cadmium carcinogenesis occurs via up-regulation of translation factors
Esophageal Cancer - Study proposes surgical approach to invasive cancer of the distal esophagus
Finance - Cancer drug discovery company announces public offering of common stock
Financing - $6.5M in funding to advance device technology
Financing - Bone disease biotech company closes $1.6M financing
Food-borne Disease - Farm-raised salmon presents greater health risks than salmon from the wild
Gastric Cancer - Researchers review surgically treated gastric cancer in the U.S., 1988-2000
Gastroenterology - Both roxatidine and cimetidine exert an antiangiogenic effect on colon cancer
Adverse Drug Effects - Inorganic arsenic therapies may have toxic side effects
Gastroenterology - Nuclear factor kappaB inhibition impairs pancreatic cancer angiogenesis
Gastrointestinal Cancer - PET scans superior in revealing response to treatment for GISTs
Gene Delivery - U.S. patents issued for gene delivery technologies
Glioblastoma - Iressa phase II trial data published
Glioblastoma - Scientific journal reports on ZFP repression of VEGF-A
HIV/AIDS Cancer - Rhesus monkey Rhadinovirus valuable as KSHV model
Head and Neck Cancer - New mutant FasL gene therapy controls nasopharyngeal carcinoma growth
Heart Disease - Perfluorocarbon-based blood substitute to undergo phase II clinical testing
Heart Disease Risk - Insulin-like growth factor-1 protects myocardial tissue against ischemia
Helicobacter Pylori - Antibiotics may help stop stomach cancer
Adverse Drug Effects - Lamivudine prevents rituximab-induced hepatitis B virus reactivation
Helicobacter Pylori - Essential oils are not effective as anti-Helicobacter agents
Hematology - Liver cancer rates parallel the aging of thalassemic populations in Italy
Hepatic Carcinoma - Mortality from intrahepatic cholangiocarcinoma may be increasing in Scotland
Hepatitis B Virus - Hepatitis B virus X protein does not impair nucleotide excision repair
Hormone Therapy - Drop in hormone therapy use shows doctors heed research findings
Human Papillomavirus - California organization says it will be first to use HPV test routinely
Immunology - Cancer researchers unlock secrets of how tumors hide
Immunotherapy - Endoglin antibody works with transforming growth factor-beta to stop cancer
Infection - Quinupristin/dalfopristin may be effective against Gram-positive infections
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