Anticancer Therapy

Cisplatin does not directly effect mitochondrial oxygen consumption

Published in Cancer Weekly, February 3rd, 2004

Study finds that exposures to alkylating agents and anthracyclines produce immediate and dose-dependent impairment of mitochondrial oxygen consumption.

According to recent research published in the journal Biochemical Pharmacology, "The evolving role of mitochondria as a target for many anticancer drugs (e.g. platinum-based compounds, alkylating agents and anthracyclines) prompted us to investigate their immediate effects on the mitochondrial respiratory chain."

"For this purpose, we used a phosphorescence analyzer that measures O₂ in solution. The O₂ of solutions containing an appropriate substrate and various cell...

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Source: Cancer Weekly (2004-02-03)

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