Published in Cancer Weekly, February 3rd, 2004
"Somatic loss of heterozygosity (LOH) has been widely reported in breast cancer as a means of identifying putative tumor-suppressor genes. However, individual studies have rarely spanned more than a single chromosome, and the varying criteria used to declare LOH complicate efforts to formally differentiate regions of consistent versus sporadic (random) loss," scientists in the United States report.
"We report here the compilation of an extensive database from 151 published LOH studies of breast cancer, with summary...
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