Developmental Biology

Regulating folate receptors during folate deficiency

Published in Cancer Weekly, February 3rd, 2004

Folate, a type of B vitamin, is important in DNA synthesis, and folate deficiency can lead to fetal abnormalities in spinal cord and brain development. Folate receptors (FRs) have been shown to mediate cellular folate uptake in both normal and malignant cells.

In the Journal of Clinical Investigation, Asok Antony and colleagues from Indiana University demonstrated the mechanism of FR upregulation under conditions of folate deficiency. The authors had previously demonstrated that a cis-element and trans-acting protein regulate FR synthesis.

In the current study they examined the expression of FRs in human cervical cancer cells after transfer...

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Source: Cancer Weekly (2004-02-03)

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