Leukemia

Adaphostin can damage both myeloid and lymphoid leukemia cells

Published in Cancer Weekly, February 10th, 2004

Adaphostin might have a broader spectrum of activity than originally envisioned, researchers say.

"Adaphostin (NSC 680410), an analog of the tyrphostin AG957, was previously shown to induce Bcr/abl downregulation followed by loss of clonogenic survival in chronic myelogenous leukemia (CML) cell lines and clinical samples," investigators in the United States report.

"Adaphostin demonstrated selectivity for CML myeloid progenitors in vitro and remained active in K562 cells selected for imatinib mesylate resistance. In the present study, the mechanism of action of adaphostin was investigated in greater detail in vitro," wrote J. Chandra and colleagues,...

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Source: Cancer Weekly (2004-02-10)

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