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Lung Cancer

Endostatin prevails in nonmalignant and malignant pleural effusions

Published in Cancer Weekly, February 10th, 2004

Endostatin prevails in nonmalignant and malignant pleural effusions.

"Endostatin is an angiogenesis inhibitor that is an endogenously produced proteolytic fragment of type XVIII collagen. Although serum levels of endostatin have extensively been studied in patients with malignant diseases, endostatin in pleural effusion has not been fully evaluated. In order to determine whether endostatin is present in pleural effusion, and to determine whether endostatin levels vary in pleural effusion of different etiology, we measured levels of endostatin in 38 malignant pleural effusion due to lung cancer patients and 29 patients with non-malignant disease using an ELISA kit,"...

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