Oncogenesis
Interplay between hypoxia- and estrogen-dependent signaling rules breast cancer
Published in Cancer Weekly, February 17th, 2004
"Angiogenesis activation mediated by vascular endothelial growth factor (VEGF) is one of the factors that can cause antiestrogen treatment failure in estrogen receptor (ER)-positive breast cancer patients. Since VEGF synthesis is modulated not only by hypoxia but also by steroid hormones, we investigated the relationship between hypoxic and estrogenic/antiestrogenic stimuli in two human breast cancer cell lines expressing both ER6alpha and ERbeta (MCF7) or only ERbeta (MDA-MB231)," researchers in Italy wrote.
"In both cell lines, the VEGF level was significantly...
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Source: Cancer Weekly (2004-02-17)
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