Breast Cancer

New mode of action discovered for tamoxifen

Published in Cancer Weekly, February 17th, 2004

University of Iowa researchers have discovered a new mode of action for tamoxifen, which could lead to better targeting of the therapy and possibly the development of new anti-cancer drugs.

First used to treat breast cancer more than 30 years ago, tamoxifen now is one of the most widely used breast cancer therapies.

In breast tissue, tamoxifen acts as an anti-estrogen, meaning that it blocks the action of the hormone estrogen. Normal breast cells grow in response to estrogen in a controlled fashion. However, in breast cancer, this cell growth is out of control. Treatment with the anti-estrogen tamoxifen inhibits the uncontrolled cell growth and keeps...

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Source: Cancer Weekly (2004-02-17)

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