Cancer Therapy
Human papillomavirus L1 renders cells susceptible to NK-mediated destruction
Published in Cancer Weekly, February 17th, 2004
According to new research from Poland, "the aim of the present study was to characterize natural cell-mediated cytotoxicity against COS-7 cells transfected with potentially oncogenic HPV-8 L1 DNA sequences cloned in sense and antisense orientation and to evaluate their lysis by peripheral blood lymphocytes (PBL) from patients with epidermodysplasia verruciformis (EV), a rare disease associated with life-long infection by specific HPV types."
"COS-7 cells were transfected with HPV-8 Hinc II restriction fragment (nucleotide positions 5434-7654) cloned in sense (COS-LIS) and...
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Source: Cancer Weekly (2004-02-17)
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