Published in Cancer Weekly, February 24th, 2004
"Nucleoside analogs are successful, widely used antiviral and anticancer therapeutics," scientists in Wales explained. "Nucleotide prodrugs (i.e, pronucleotide) have increasingly been used to improve in vivo efficacy of nucleoside analogs."
In a recent study, D. Siccardi and colleagues at the University of Wales "evaluated the permeability of a series of phosphoramidate triester prodrugs of the anti-HIV drug 2', 3'-didehydro-2', 3'-dideoxythymidine across monolayers of Caco-2, Madin-Darby canine kidney (MDCKII) epithelial cell line, and its recombinant clone...
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