Published in Cancer Weekly, February 24th, 2004
According to recent research published in the journal Expert Opinion on Investigational Drugs, "thiazolidinediones (TZDs) are synthetic ligands that activate the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPAR-gamma). These compounds are widely used in the treatment of Type 2 diabetes. TZDs have antitumour activity in a wide variety of experimental cancer models, in vitro and in vivo, by affecting the cell cycle, induction of cell differentiation and apoptosis as well as by inhibiting tumor angiogenesis."
"These effects are mediated through both...
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