Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . March 2nd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Cancer Risk - More cancers have genetically caused types than previously thought
Cancer Therapy - Proteasome is target for cancer therapy
Cancer Therapy - Tumor cell-specific therapy shows preclinical promise
Computational Biology - New mathematical algorithms might help diagnose cancer
Melanoma - New way found to predict metastasis
Oncology - Protein cross-talk regulates mesothelial cancer cell proliferation
Advanced Melanoma - FDA approves Genasense NDA
Anticancer Agent - Betula platyphylla var. japonica extract may have anticancer properties
Basal Cell Carcinoma - Risk of basal cell carcinoma is increased by alcohol intake
Bladder Cancer - Alkaline comet assay predicts bladder cancer cell radiosensitivity
Blood Vessels - Alphastatin is a potent inhibitor of activated endothelial cells
Body Mass Index - PA health department study shows 18% of 8th graders overweight
Brain Hematoma - MRI and CT can be used to diagnose intracerebral hematoma
Brain Tumor Model - Genetic patterns were stable in human malignant glioma xenografted in nude mice
Breast Cancer - A new assay detects MGB1 transcript in the blood of breast cancer patients
Breast Cancer - An informational video can improve breast cancer clinical trial knowledge
Breast Cancer - CHEK2*1100delC germline mutation carriers are at risk for another breast tumor
Breast Cancer - Combo GET therapy well tolerated in metastatic breast cancer
Breast Cancer - FDA accepts NDA with priority review for RSR13
Breast Cancer - Free estradiol and breast cancer risk can be calculated for use in studies
Breast Cancer - Full-field breast ultrasound complements mammography
Breast Cancer - Gabapentin reduces tamoxifen-induced hot flashes in women with breast cancer
Breast Cancer - Immune response to telomerase tumor antigen studied as possible vaccine
Breast Cancer - Mammography more stressful for survivors of disease
Breast Cancer - Much breast cancer treatment in clinical practice does not follow guidelines
Breast Cancer - Mutations, especially 11q loss, may be involved in early-onset breast tumors
Breast Cancer - Paget carcinoma cells differ from those of the underlying carcinoma
Breast Cancer - Sarcomas of the breast prone to relapse unless wide surgical margains attained
Breast Cancer - Spanish women with family history need education about breast cancer
Breast Cancer - Two drinks a day increases risk of breast cancer, study shows
Breast Density - Higher breast density is associated with increased breast cancer risk
Breast Pain - New estrogen inhibitor in phase II development
Business & Finance - Cancer center lays off 89 employees amid insurance dispute
Business & Finance - Cialis maker reports results for 2003
Business & Finance - Small molecule drug company files registration statement for IPO
Business Update - Drug discovery company announces name change, new appointments
Business Update - Pharmaceutical company announces dismissal of all lawsuits
CNS Diseases - FLAIR-MRI can detect abnormal hyperintensity within the subarachnoid space
Cancer - New research may lead to orally administered small-molecule cancer drug
Cancer - New web site provides online support for teens with cancer
Cancer Metastasis - Insulin-like growth factor-I receptor fosters tumor invasion and metastasis
Cancer Registries - Breast cancer risk differs within the South Asian female population in England
Cancer Research - Researchers develop a new protocol for verifying data
Cancer Screening - Not all tests should be advocated
Cancer Therapy - Bill to offer cancer treatment to poor women clears first hurdle in Oklahoma
Cancer Therapy - Fourth phase II trial initiated for new stem cell transplantation drug candidate
Cancer Therapy - IRESSA (gefitinib) added to ASCO practice guidelines
Cancer Therapy - Indiana's mega-million proton therapy cancer center welcomes its first patients
Cancer Therapy - TNP-470 blocks carcinosarcoma-induced tube formation
Cancer Therapy - The ZD55-gene therapy system is a potent anticancer tool
Cancer Therapy - Tumor growth is inhibited by targeted alliinase delivery
Cancer Therapy - Update provided on Polymer Platinate AP5346 program
Cancer Vaccine - Cancer vaccines use high molecular weight stress proteins
Cancer and Aging - Nutrition contributes to aging and cancer development
Cell Biology - Ras activation causes endothelial cells to acquire an angiogenic phenotype
Cell Division - Research shows how cells ensure genetic material shared evenly between daughters
Cervical Cancer - HPV, chromosome aberrations correlate with transition to microinvasive carcinoma
Cervical Cancer - In situ hybridization techniques may be able to detect HPV
Cervical Cancer - Optical detection system plus colposcopy yields improved detection rates
Cervical Cancer - Publication points to increasing use of HPV testing in cervical cancer screening
Chemotherapy - Corticosteroids alone reduced cisplatin-induced delayed emesis
Chemotherapy - Lamivudine maintains adriamycin intensity in hepatitis B patients with lymphoma
Childhood Cancer - A model can estimate glomerular filtration rate in pediatric cancer patients
Chronic Obstructive Pulmonary Disease - FDA approves Spiriva HandiHaler
Clinical Trial Trends - Mistrust limits minority representation in U.S. biomedical research
Clinical Trials - Group develops ethical strategies to use when seeking informed consent
Collaborations - Drug discovery and development collaboration amended
Collaborations - Genetronics announces strategic alliance
Collaborations - Integrated BioPharma sub, Purdue gene-transfer study results published
Collaborations - Marketing agreement signed for promotion of aspergillus test
Collaborations - Milestone payment made in anticipation of NDA filing of Clofarabine
Colon Cancer - A dominant-negative mutant of the c-Jun gene stems colorectal cancer growth
Colon Cancer - Estrogen may have protective effect, study finds
Colon Cancer - Patients are moderately shocked about a screening-detected diagnosis of cancer
Colon Cancer - U.K.'s urgent referral standard hampered by system delays
Colon Cancer - Xeloda shows promising tolerability results in colon cancer study patients
Colorectal Cancer - FDA approves Erbitux for metastatic disease
Drug Development - Researchers use human genome to design drugs
Ear Canal Cancer - Parotid may be invaded by squamous cell external auditory canal carcinoma
Endometrial Cancer - ERT poses little recurrence risk for women treated for early-stage disease
Endometrial Cancer - Prolonged menstruation is associated with developing endometrial cancer
Environmental Toxins - CDC asking EPA to test suspect environmental contaminant in Sierra Vista
Esophageal Cancer - Staging esophageal cancer with endoscopic MR imaging is safe
Esophageal Carcinoma - Chemoradiation is effective in patients with inoperable esophageal carcinoma
Finance - Campath continues steady sales progression
Finance - Ceplene maker reports net loss for first quarter
Finance - Developer of proteomics-based diagnostic products reports increased revenues
Finance - Drug discovery company reports 2003 financial results
Finance - Enzyme company completes $9.2 million financing
Finance - Imaging company reports slight revenue increase
Finance - Synthetic DNA company announces conversion of series A preferred stock
Gastric Cancer - Green tea does not protect against stomach cancer, study finds
Gastric Cancer - Highly salted foods increase gastric cancer risk in Japanese men and women
Gastric Cancer - S-1 combined with cisplatin is active against advanced gastric cancer
Gastric Tumors - Epstein-Barr virus and Helicobacter pylori may be causes of gastric cancer
Gastrointestinal Cancer - Gemcitabine and mitomycin C may be effective in treating advanced GI cancer
Gastrointestinal Tumors - Gene clustering analysis may serve as molecular markers for gastric adenoma
Gastrointestinal Tumors - Tumor suppressor gene hypermethylation may predict GI stromal tumor behavior
Genetic Disorder - Mentally retarded patients without 15q11-q13 defects should have MECP2 analysis
Genomics - Biotechnology and medical genomics partnership awards research grants
Graft-versus-Host Disease, - CD4+ T cells mediate syngeneic graft-versus-host disease-associated colitis
Gynecology - LPA type-2 regulates a host of growth factors to control ovarian activity
Gynecology - VRAM flaps are favored over other types for vaginal reconstruction
HIV/AIDS Therapy - Houston firm set to begin human trials of new HIV treatment
Head and Neck Cancer - Hepatitis C virus infection raises the risk for oral squamous cell carcinoma
Head and Neck Cancer - IL-13 receptor alpha 2 chain is marker of head and neck cancer
Head and Neck Cancer - Vascular endothelial growth factor isoforms are detected in oral carcinomas
Hematology - Platelet microparticles contribute to the formation of new blood vessels
Hepatic Cancer - Cotara phase I hepatic cancer study published in cancer journal
Hepatic Duct Cancer - Segment III intrahepatic cholangiojejunostomy is modified to reduce bile leakage
Human Papillomavirus - Adenovirus expressing papillomavirus E2 protein eliminates infection
Human Papillomavirus - Prevention of cervical cancer through HPV vaccination reviewed
Imaging - Hologic inks agreement for Direct-to-Digital General Radiography systems
Imaging - Imaging company reports order for CTLM system from Axies Medical
Immunology - Human mast cells could be regulated to control VEGF production
Immunology - ImmuneRegen appoints new member to its scientific advisory board
Infectious Disease - Panfungal PCR useful for cerebral aspergillosis diagnosis
Leukemia - Infectious diseases in the first year of life may protect against ALL
Leukemia - Massive hyperdiploidy and tetraploidy are rare in AML
Leukemia - Road traffic exhaust might be involved in childhood leukemia
Leukemia Therapy - Imatinib inhibits hematopoietic progenitor cell proliferation
Leukemia Therapy - Late CMV PRP reported after stem-cell transplantation
Leukemia Therapy - Unrelated cord blood transplantion feasible for adult AML patients
Lung Cancer - Bronchial washings are not reliable in diagnosing carcinoid lung tumors
Lung Cancer - CPT-11+ cisplatin results in better survival than etoposide+cisplatin
Lung Cancer - Carboplatin and prinomastat prolongs survival in an aggressive lung cancer model
Lung Cancer - Diet and genetics are related to lung cancer susceptibility
Lung Cancer - Epidermal growth factor receptor-targeted therapy improves symptom in NSCLC
Lung Cancer - FDA approves Alimta-cisplatin combination
Lung Cancer - FDA panel recommends approval of new CAD system
Lung Cancer - Gemcitabine given at home is safe in advanced non-small cell lung cancer
Lung Cancer - Non-small cell lung tumors regrow quickly after induction chemotherapy
Lung Cancer - Nonsmokers get a lung carcinogen from environmental tobacco smoke
Lung Cancer - PET scan is a useful adjunct in the staging of non-small cell lung cancer
Lung Cancer - Patient education is important in targeted therapy for lung cancer
Lung Cancer - Researchers propose follow-up of patients with non-small cell lung cancer
Lung Cancer - Sarasar clinical study in non-small cell lung cancer discontinued
Lung Cancer - Video-assisted thoracoscopy is useful for preoperative staging NSCLC
Lung Carcinoma - Gamma knife stereotactic radiosurgery is useful for solitary brain metastases
Lymphoma - API2-MALT1-positive tumors are more aggressive in colorectal lymphoma
Lymphoma - Etoposide and thiotepa is an effective preparative regimen for autologous BMT
Lymphoproliferative Disease - Reduced-intensity BEAM-alemtuzumab SCT effective
Market Analysis - Explosive growth to push cancer vaccine market past $1B
Metastasis - Tumors can be triggered in normal cells by signals from nearby supporting cells
Mucositis - Disappointing results reported for phase II clinical trial of repifermin
Multidrug Resistance - Antivascular therapy offers an option for bypassing drug-resistant tumors
Nasopharyngeal Carcinoma - Nasopharyngeal cancer is rare in young patients and often presents late
Nephrotoxicity - Cell cycle inhibitors protect murine renal cells from cisplatin toxicity
Nerve Injury - Green tea polyphenol preserves rat peripheral nerves for 1 month
Neuroblastoma - Combined therapy can benefit neuroblastoma patients in the high-risk group
Non-Hodgkin Lymphoma - Orphan drug designation granted by FDA for BCX-1777
Non-Small Cell Lung Cancer - Gefitinib in pretreated elderly patients with advanced NSCLC is effective
Nursing - Three-day programs can improve nurses' communication skills in cancer care
Nutrition - Copper may play role in "starving" cancer to standstill
Oncogenes - Newly discovered cancer mutation arrived with immigrant almost 3 centuries ago
Oncogenes - Scientists screen fruit fly genome for cancer-relevant genes
Oncogenesis - Membrane type-1 matrix metalloproteinase encourages melanoma invasion
Oncogenesis - Truncated hepatitis B virus X gene sequences associate with liver cancer
Oncology - 5-Fluorocytosine increases the toxicity of oncolytic viruses
Oncology - Additional data on mechanism of action of KRX-0401 published
Oncology - Joint targeting of pericytes and endothelial cells encourages tumor regression
Oncology - Signals from vascular endothelial cells sustain tumors prior to angiogenesis
Oncology - The insulin-like growth factor axis encourages liver cancer formation
Osteoporosis - Ketan Desai to lead clinical development
Ovarian Cancer - Consolidation therapy with paclitaxel is effective in ovarian cancer
Ovarian Cancer - Estrogen inhibits paclitaxel-induced apoptosis in ovarian cancer cell lines
Ovarian Cancer - Guidelines help patients receive proper referrals for specialized treatment
Ovarian Cancer - Ovarian cryopreservation is an option if in vitro fertilization is not possible
Ovarian Cancer - Paclitaxel-carboplatin is a widely used standard therapy for ovarian cancer
Ovarian Cancer - Radiotherapy resulted in better progression-free survival for ovarian cancer
Ovarian Cancer - The paclitaxel-cisplatin regimen is beneficial in advanced ovarian cancer
Ovarian Cancer - Three-drug regimen produced more complete responses in ovarian cancer
Ovarian Cancer - US, CT, and MRI are all accurate in staging ovarian cancer
Pancreatic Cancer - New cancer test expands tumor marker menu on immunoassay systems
Pancreatic Cancer - Researchers use ProteinChip technology to discover novel biomarkers
Pancreatic Cancer - Tumor RNA-pulsed dendritic cells treat pancreatic tumors in mice
Parotid Tumors - MR imaging of parotid tumors may help identify benign vs. malignant masses
Patents - U.K. charity gets breast cancer gene patent
Patents - U.S. patent granted covering methods to inhibit Hedgehog pathway
Pediatric Oncology - Discrepancies in long-term care of childhood cancer survivors exposed
Personnel - Breast cancer expert becomes nutraceutical research company's medical director
Personnel - Dr. Vincent F. Simmon named chief operating officer
Personnel - Drug discovery company announces new vice president
Personnel - Genomics company appoints Dana B. Hosseini president and CEO
Pesticides - Study shows agricultural workers' pesticide exposure varies by job task
Postoperative Plegia - Some anesthetic agents negatively affect motor evoked potentials
Prostate Cancer - Cruciferous vegetables may be protective during early prostate tumorigenesis
Prostate Cancer - Estramustine alone or combined with vinblastine yields highly toxic side effects
Prostate Cancer - Genetic fingerprinting finds associations between prostate cancer and BPH
Prostate Cancer - Increased cholesterol in prostate tumor cell membranes may be linked to cancer
Prostate Cancer - Low-fat diet slows cancer growth, increases survival times in laboratory models
Prostate Cancer - Pharmaceutical company discovers prostate cancer biomarker
Prostate Cancer - Ras signaling may be responsible for prostate cancer progression
Prostate Cancer - Researcher receives $9 million grant to launch gene therapy trials
Prostate Cancer - Satraplatin phase III multinational registrational trial in Europe expanded
Prostate Cancer - Studies indicate an inverse association of aspirin and prostate cancer
Prostate Cancer - The level of testosterone in the serum is likely unrelated to prostate cancer
Prostate Cancer - ThermoDox study expanded; FDA allows two amendments
Prostate Cancer - Understanding apoptosis key to effective prostate cancer therapy
Prostate Cancer - Update announced on clinical trials of Triapine as a single agent
Rectal Cancer - Race may be a factor in treatment of cancer patients
Renal Cancer - Germline SDHB mutations can predispose to early-onset renal cell carcinoma
Renal Tumors - Imaging technology for renal tumors cannot determine diagnosis
Reporter Gene - Construction of a reporter system can detect fine differences in p53 activation
Skin Cancer - Preventive efforts must increase to reduce the incidence of skin cancer
Smoking Cessation - Occupation plays significant role in smoking cessation, study shows
Stem-Cell Research - Electroporation augments the transfection of marrow stromal cells
Stem-Cell Research - Immune response makes stem cells transduced by lentiviral vectors disappear
Stem-Cell Transplantation - Novel membrane reactor enhances cord blood cell expansion
Stem-Cell Transplantation - RIC SCT feasible for patients with advanced solid tumors
Stem-Cell Transplantation - Treosulfan-fludarabine conditioning regimen safe and effective
Stomach Cancer - Results reported in phase II trial of G17DT in combination with cisplatin, 5-FU
Testicular Cancer - Patients with testicular cancer had less distress than other cancer patients
Testicular Tumors - Bilateral germ-cell tumors of the testis are more common in younger men
Thromboembolism - Cancer patients are at high risk for recurrent thromboembolism
Treatment Decisions - Research suggests an approach to shared decision making about cancer issues
Tumors of Unknown Primary Origin - Patients with cancer of unknown primary origin survive longer with treatment
Viral Proteomics - Hepatitis B virus X protein uses HIF-1 alpha to stimulate angiogenesis
Wilms Tumor - Wilms tumors with unfavorable histology had abnormalities of 17p
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