Published in Cancer Weekly, March 2nd, 2004
According to published research from the United States, "The proteasome is a multicatalytic proteinase complex responsible for the degradation of most intracellular proteins, including proteins crucial to cell cycle regulation and programmed cell death, or apoptosis. In preclinical cancer models, proteasome inhibitors induce apoptosis, have in vivo antitumor efficacy, and sensitize malignant cells and tumors to the proapoptotic effects of conventional chemotherapeutics and radiation therapy."
"Interestingly, transformed cells display greater susceptibility to proteasome inhibition than nonmalignant...
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