Published in Cancer Weekly, March 2nd, 2004
Cells with p53 mutations can escape these constraints, leading to the uncontrolled growth characteristic of "immortal" cancer cells. Nearly all types of tumors have mutations in the p53 pathway, many of them in the p53 gene itself. Treatments focused on restoring p53 function - which is lost selectively in cancer cells - should prove more effective than standard therapies that indiscriminately target all dividing cells.
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