Hyperparathyroidism

Some types of familial isolated hyperparathyroidism have unknown cause

Published in Cancer Weekly, March 9th, 2004

Mutations in the HRPT2 gene are not responsible for the development of familial isolated hyperparathyroidism (FIHP).

"Familial isolated hyperparathyroidism (FIHP) can result occasionally from the incomplete expression of a syndromic form of familial hyperparathyroidism (HPT), specifically multiple endocrine neoplasia type 1 (MEN1), familial hypocalciuric hypercalcemia, or the hyperparathyroidism-jaw tumor syndrome (HPT-JT)," scientists in the United States report.

"The cause of FIHP has not been identified in the majority of families. We investigated 32 families with FIHP to determine the frequency of occult mutation in HRPT2, the gene causing...

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Source: Cancer Weekly (2004-03-09)

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