Published in Cancer Weekly, March 9th, 2004
MDS "are a heterogeneous group of bone marrow (BM) diseases," oncologists in the Netherlands explained. "MDS patients suffer from bone marrow failure because of the expansion of a malignant clone, resulting in abnormal differentiation of blood cells and severe pancytopenias." These patients also have "a high propensity for the development of acute myeloid leukemia (AML)."
"During the last few years it has become increasingly clear that MDS is a stem cell disease," noted J.P. van Dijk and colleagues at the University of Nijmegen. "Two methods have generally been used to study the clonal origin of...
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