Wasting Syndrome

Ghrelin upregulated in cachectic nude mice bearing human melanoma cells

Published in Cancer Weekly, March 9th, 2004

Ghrelin expression in upregulated in cachectic nude mice bearing human melanoma cells.

"Ghrelin is a gastrointestinal peptide that stimulates food intake and growth hormone (GH) secretion. We studied the biosynthesis and secretion of ghrelin in a cancer cachexia mouse model. G361, a human melanoma cell line, was inoculated into nude mice," scientists in Japan report.

"The body weight was reduced and the plasma concentration of interleukin-1beta (IL-1beta) was markedly higher in tumor-inoculated mice compared with vehicle-treated mice," stated Takeshi Hanada and colleagues at Miyazaki Medical College. "Furthermore, white adipose tissue (WAT) weight,...

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Source: Cancer Weekly (2004-03-09)

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