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Breast Cancer

Gamma-tocotrienol can induce apoptosis in human breast cancer cells

Published in Cancer Weekly, March 9th, 2004

Cytochrome c may not be the critical protein released from mitochondria that triggers gamma-tocotrienol-induced apoptosis in MDA-MB-231 cells, researchers say.

"Tocotrienols, which are Vitamin E isoforms, are known to inhibit the growth of human breast cancer cells due partly to apoptosis. However, the characterization of tocotrienol-induced apoptosis is incomplete, particularly what happens during the initiation phase that precedes execution of the cells," investigators in the United States report.

"The objective of this study was to clarify the apoptotic effects of tocotrienols, with especial emphasis in determining if the mitochondria-mediated...

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