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Gene Transfer

A novel tissue-specific promoter system provides controlled gene expression

Published in Cancer Weekly, March 16th, 2004

A novel tissue-specific promoter system provides controlled gene expression.

According to recent research from Japan, "present cancer gene therapy using proapoptotic genes has had limited success because the therapy is prone to cause side effects as a result of the lack of tissue and cancer specificity. To target cancer cells without damaging normal cells, we have designed a novel dual promoter system in which a tissue-specific transcription system under the control of a cancer-specific promoter drives expression of a therapeutic gene. The applicability of this system was demonstrated by adapting it to target lung cancer."

"We termed this lung cancer...

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