Bladder Cancer
Clusterin suppression makes bladder cancer cells more sensitive to cisplatin
Published in Cancer Weekly, March 16th, 2004
According to scientists writing in the journal Cancer Letters, "we examined the functional role of clusterin in chemotherapy-induced apoptosis and tested whether antisense transfection targeted against clusterin enhances the chemosensitivity in human bladder cancer cells in vitro. Clusterin mRNA and protein expression of 253J cells, a human bladder carcinoma cell line, after treatment with cisplatin were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis. Clusterin expression and cell growth were compared between 253J cells transfected with a...
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Source: Cancer Weekly (2004-03-16)
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