Immunology
Autologous endothelium vaccination uses autoimmune response to halt colon cancer
Published in Cancer Weekly, March 16th, 2004
"Overcoming immune tolerance of tumor angiogenesis should be useful for adjuvant therapy of cancer. We hypothesized that vaccination with autologous endothelium would induce an autoimmune response targeting tumor angiogenesis. To test this concept, we immunized BALB/c mice with a vaccine of glutaraldehyde-fixed murine hepatic sinusoidal endothelial cells (HSEs) in a lung metastasis model of Colon-26 cancer," scientists writing in the journal Cancer Science report.
"Vaccination with autologous HSEs induced both preventive and therapeutic anti-tumor immunity that...
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Source: Cancer Weekly (2004-03-16)
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