Transgenic mouse model for breast cancer developed

"We have analyzed mammary tumors arising in transgenic mice expressing a novel, multifunctional RNA-binding protein. The protein, which we call the c-inyc mRNA coding region instability determinant binding protein (CRD-BP), binds to c-myc, insulin-like growth factor 11, and beta-actin mRNAs, and to H19 RNA. Depending on the RNA substrate, the CRD-BP affects RNA localization, translation, or stability," scientists in the United States report.

"CRD-BP levels are high during fetal development but low or undetectable in normal adult tissues," said Charles R. Tessier and colleagues at...

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