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Breast Cancer Therapy

Regulatory nodes coordinating signaling are potential breast cancer targets

Published in Cancer Weekly, March 16th, 2004

Regulatory nodes that integrate and coordinate signaling are potential targets for breast cancer therapy.

According to published research from the United States, "Blockade of the estrogen receptor (ER) with anti-estrogens and aromatase inhibitors is effective in the treatment of breast cancer. Why ER plays such a dominant role in breast cancer and represents such an excellent target remains to be defined. The ability of ER to respond to multiple inputs and to control expression of multiple downstream genes may be one of the reasons why ER is such a powerful target for breast cancer treatment."

"The recent modest performance of a number of targeted...

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