Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . March 23rd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Cancer Therapy - New study distinguishes drug-induced from apoptosis-associated DNA damage
Retinoblastoma - Protein's role in retina development key to understanding devastating eye cancer
Colorectal Cancer - New way of increasing efficacy of chemotherapy described
Environmental Toxins - Cancer health risk significantly underestimated by EPA's ambient model estimates
HIV/AIDS Cancer - HIV Tat linked to liver tumor development
Pediatric Oncology - Teens and young adults the new frontier in cancer, says U.S. specialist
Acoustic Neuromas - Study finds no connection between cell phone use and risk of acoustic neuroma
Adverse Drug Effects - Tumor necrosis factor signals mediate acetaminophen-induced liver injury
Antimicrobials - Genistein has potent antistaphylococcal activity
Bile Duct Cancer - Most bile duct and gallbladder carcinomas are adenomas
Bladder Cancer - Occupational chemical exposure is a major cause of urological cancer
Bladder Cancer - Smoking cigarettes increases risk of bladder cancer substantially
Bladder Cancer - Smoking significantly increases the risk of developing bladder cancer
Bone Cancer - COX-2 inhibitors may be promising in treating bone cancer pain
Bone Cancer - Radiation treatment is active in bone cancer
Bone Tumors - No recurrence seen in patients with bone graft substitutes for benign bone tumors
Bone Tumors - Telomerase activity is related to the progression and invasion of bone cancer
Brain Cancer - For brain tumor surgery in children, high-volume hospitals get better results
Brain Cancer - Tie2 activation can be targeted for the treatment of astrocytoma
Brain Tumors - Abnormalities occur after whole brain radiotherapy for low-grade glioma
Brain Tumors - Certain brain tumors are clustered with other neoplasms in families
Brain Tumors - Combined drug regimen shows promise in treating recurrent malignant brain tumors
Brain Tumors - Harvey W. Cushing developed posterior fossa surgery for children's brain tumors
Brain Tumors - Left intracranial tumors impair picture recognition memory
Brain Tumors - Linear accelerator-based radiosurgery is used for skull base meningiomas
Brain Tumors - Signal regulatory protein alpha is expressed on astrocytomas
Breast Cancer - Common endocrine therapies modulate local feedback mechanisms in breast cancer
Breast Cancer - Company accomplishes breast endoscope milestone
Breast Cancer - FDA approves BreastScan IR for early detection of breast cancer
Breast Cancer - Grant to fund development of implantable sensor technology for oncology
Breast Cancer - Imaging Diagnostic Systems installs additional CTLM system
Breast Cancer - Multiple biomarkers may be necessary to classify breast cancer
Breast Cancer - New test detects early cellular changes
Breast Cancer - Parabens are found in human breast tumors
Breast Cancer - Research focuses on protective role of vitamin A
Breast Cancer - Risk of breast cancer may be increased by the length of the egfr CA SSR gene
Breast Cancer - Study evaluates psychosocial functioning in women after prophylactic mastectomy
Breast Cancer - Study tests human detection of lesions in mammograms
Breast Cancer - The antimetastatic gene NM23 controls several functional pathways
Breast Cancer - Unique loss of heterozygosity patterns exist in different breast cancer groups
Breast Cancer - Widely used antinausea drug may interfere with chemotherapy
Breast Cancer - Women's well-being worse after mastectomy, chemotherapy, than lumpectomy
Breast Cancer - [18F]FDG-GPET is useful in the follow-up of breast cancer patients
Breast Cancer Model - Pregnancy has a protective effect against breast cancer
Business & Finance - Australian drug-development company on track to meet milestones
Business Update - CEO discusses Lymphoseek development
Cancer - Biotech company announces publication of drug-target interaction technology data
Cancer - Patent issued for vasopermeation enhancement technology
Cancer - Selective small molecule inhibitor of the Aurora kinases reduces tumor growth
Cancer Database - First standardized cancer database to be compiled by medical centers
Cancer Epidemiology - Cancer rates in teens and early 20s rising
Cancer Markers - Cyclin E overexpression in some cancers means proliferation and poor prognosis
Cancer Prevention - Conjugated linoleic acid isomers have unique effects on angiogenesis
Cancer Therapy - Company announces expansion and modification of phase I trial for OSI-461
Cancer Therapy - FDA approves Avastin for first-line metastatic colorectal cancer patients
Cancer Therapy - Irsogladine side-steps angiogenic function to stop breast cancer metastasis
Cancer Therapy - Latest preclinical study suggests broader potential utility of MDM2 antisense
Cancer Therapy - Patient enrollment begins in phase III recurrent head and neck cancer studies
Cancer Therapy - Vascular remodeling after antiangiogenic therapy marks tumor recurrence
Cancer Vaccine - IL-12 enhances generation of tumor antigen-specific Th1CD4 T cells
Cell Biology - Protein sequences not so predictable after all
Cerebral & Spinal Surgery - Transcranial electrical stimulation with screw electrodes is effective
Cervical Cancer - Cervical screening programs can be monitored by using cytology outcomes
Cervical Cancer - Clinical trials begin for noninvasive cervical cancer detection test
Cervical Cancer - Frequent hypermethylation of TIMP-2 gene may promote cervical cancer development
Cervical Cancer - Phenoxodiol trial begins at Yale
Chondrosarcomas - FDG PET imaging is effective in tumor grading of chondrosarcomas
Collaborations - Alliance to develop fully human monoclonal antibodies for cancer treatment
Collaborations - Alliance to develop new approaches to proteomics-based diagnostics
Collaborations - Exclusive rights to patented cancer treatment obtained
Collaborations - Three-year distribution agreement signed for cancer detection system
Colon & Lung Cancer - Inactivation of p16 in NSCLC and colorectal cancer has different clinical outcome
Colon Cancer - Bmi-1 oncoprotein is overexpressed in human colorectal cancer
Colon Cancer - HER-2 is overexpressed in many colorectal cancer tumors
Colon Cancer - Rectal bleeding is associated with increased risk of distal colon cancer
Colon Cancer - Several genes respond to intracellular zinc depletion in colon adenocarcinoma
Colorectal Cancer - Diagnosing hereditary nonpolyposis colon cancer (HNPCC) is important
Colorectal Cancer - Laparoscopic resection of colorectal cancer offers advantages
Colorectal Tumors - Smoking, more than alcohol use, increases risk of developing colorectal adenomas
DNA Vaccines - Study shows possible advance in DNA vaccines for some viral infections, cancer
Diabetes - Doxycycline blocks enzyme activity to heal chronic diabetic ulcers
Diagnostics - Fine needle aspiration can distinguish benign and malignant soft tissue lesions
Diagnostics - New imaging technique developed to identify breast cancer
Diagnostics - New nano-imaging technique could improve reliability of breast cancer tests
Diagnostics - Pharmacists make new contributions to multidisciplinary cancer care
Diagnostics - Study reveals a need for additional PET scanners in the U.K.
Diagnostics - Taiwanese cancer patients want to know the diagnosis before family is told
Diagnostics - Two-photon fluorescence sheds light on drug delivery inside tumors
Drug Delivery - Branched poly(L-glutamic acid) may be a biodegradable drug carrier
Drug Delivery - Imatinib (Glivec) has equivalent bioavailability orally and intravenously
Drug Delivery - ambIT pump line includes infusion therapies for chemotherapy and antibiotics
Drug Development - Anticancer and antimalarial agents derived from Malaysian ginseng
Endocrinology - Insulin receptor substrates play a major role in pancreatic cancer angiogenesis
Esophageal Cancer - Study examines role of Helicobacter pylori in cancer development
Eye Tumors - Tumors of the conjunctiva and cornea can be congenital or acquired lesions
Finance - Biotechnology company reports 77% increase in revenues
Finance - California biopharma completes $4.7 million private financing
Finance - Cancer drug manufacturer reports 2003 financial results
Finance - Maker of KOS-862 and 17-AAG reports $21.8 million revenue increase in 2003
Finance - Medical-products company reports 33% increase in net sales
Finance - Pharmaceutical company reports 2003 financial results
Finance - Regeneron reports 2003 financial results
Finance - Regional anesthesia sales gain 125%, propel Q4 revenue to record $13.7M
Finance - Zadaxin maker reports 2003 financial results
Gallbladder Cancer - Apolipoprotein B-100 XbaI gene may predispose patients to gallbladder cancer
Gallbladder Carcinoma - FDG-PET finds unknown metastases in 30% of cholangiocarcinoma patients
Gastric Cancer - Survivin predicts cis-diamminedichloroplatinum sensitivity in gastric cancer
Gastroenterology - Thrombospondin-1 and irinotecan combine to staunch colon cancer growth
Gene Transfer - Angiostatin gene therapy arrests tumor growth in experimental models
Gene Transfer - Retroviral constructs directed against CEA foster tumor cell transduction
Generic Drugs - IVAX enters marketing/distribution agreement for injectable paclitaxel in EU
HIV/AIDS Cancer - PAX2 plays key role in Kaposi sarcoma pathogenesis
Hodgkin Disease - As many as 95% of Hodgkin disease patients can be cured with modern therapy
Hodgkin Disease - Manufacturing agreement announced for monoclonal antibody product candidate
Hypopharyngeal Carcinoma - Computed tomography is useful in determining hypopharyngeal tumor volume
Immunology - Innate immune response relies on selectins and integrins for tumor suppression
Kaposi Sarcoma - KSHV K1 protein activates Akt cell survival pathway
Laryngeal Cancer - Exposure to cement dust is related to development of lung cancer
Laryngeal Tumors - High-grade chondrosarcomas of the larynx are rare but very aggressive
Legal Issues - GlycoGenesys files counterclaims
Leukemia - Clofarabine is active in children with advanced leukemia
Leukemia - Nipent European marketing authorizations acquired
Leukemia - Role of hematopoietic stem cells in CML reviewed
Leukemia - Totally implantable subcutaneous port system can cause extensive bleeding
Lung Cancer - Data published on GVAX lung cancer vaccine
Lung Cancer - Risk of lung cancer is increased with long-term residential exposure to radon
Lung Cancer - Standard management policies for SCLC in British Columbia are effective
Lung Cancer - Study reviews dietary carotenoids and lung cancer risk from seven cohort studies
Lung Cancer - Two new studies of Abraxane initiated in chemotherapy-naive patients
Lymphoma - Chlorambucil can be toxic to the central nervous system
Lymphoma - Combined regimen is effective and minimally toxic in non-Hodgkins lymphoma
Lymphoma - Foundation grant to support clinical and laboratory studies
Lymphoma - Researchers find direct link between CBP gene and lymphoma
Lymphoma - Researchers link unusual DNA structure to cancer
Lymphoma Therapy - Lymphocyte dose correlated with survival after auto-SCT in NHL patients
Lymphoma Therapy - Stem-cell transplant resolves pediatric hepatosplenic gammadelta T-cell lymphoma
Medicare - Cancer patients brace for changes
Medulloblastoma - Research seeks to improve treatment of a common childhood brain tumor
Melanoma - Aranoza is approved for treating patients with melanoma
Mergers and Acquisitions - Acquisition to enhance Merck's cancer research program
Mergers and Acquisitions - Genzyme Corp. to acquire oncology drug development company
Mergers and Acquisitions - Hollis-Eden announces acquisition
Metastatic Solid Tumors - Biotechnology company receives approval to begin U.K. phase I cancer trial
Multiple Myeloma - Thalomid multiple myeloma treatment sNDA accepted by FDA for review
Myeloid Disorders - New targeted agents in acute myeloid leukemia are more effective and less toxic
Myeloma - Cancer drug company announces $9.7 million common stock financing
Neuroblastoma - Angiogenesis inhibitors stop hemangioblastoma progression
Non-Hodgkin Lymphoma - Expert review highly agrees with the diagnosis of NHLs in a cancer registry
Non-Hodgkin Lymphoma - SGN-30 receives orphan drug designation for T-cell lymphomas
Non-Small Cell Lung Cancer - Gemcitabine plus cisplatin is cost effective in non-small cell lung cancer
Oncology - Antisense suppression of DENN alters the growth of cancer cells and tumors
Oncology - Apoptin expression kills human biliary tract cancer cells
Oncology - Enhanced PAR expression makes tumors form in immunocompromised mice
Oncology - Hepatitis B virus X protein makes mice more susceptible to carcinogens
Oncology - Invasive and metastatic retinoblastomas bear higher vessel densities
Oncology - Newly approved bevacizumab strikes down rectal cancer vessel growth
Oral Cancer - Salvage surgery is feasible for recurrent oral squamous cell cancer
Oral Mucositis - Orphan drug designation granted for CG53135
Oropharyngeal Cancer - Tobacco use is a major risk factor for oropharyngeal cancer in young adults
Osteosarcoma - Adolescent survival rates for bone cancer have not improved for 20 years
Osteosarcoma Model - Radiation helps cytotoxic drugs reach the tumor cells of osteosarcoma xenografts
Ovarian Cancer - Dietary folate intake may be linked to reduced risk in women who drink alcohol
Ovarian Cancer - Prostate-derived Ets exhibits strong tumor association
Ovarian Cancer - Resveratrol induces cell death in ovarian cancer cells
Pancreatic Cancer - Nerve block cuts pain in cancer patients by 50%
Pancreatic Cancer Model - Fur flies over new murine pancreatic cancer models
Personnel - Diagnostic services provider announces new member of board of directors
Personnel - Society of Gynecologic Oncologists elects new president
Pre-eclampsia - Hypertension condition during pregnancy linked to increased cancer risk
Prion Disease - Prion gene variations in chimpanzees has implication for prion diseases
Prostate Cancer - Cancer group promotes public awareness about radiation therapy
Prostate Cancer - Company identifies protein target for cancer therapy
Prostate Cancer - Familial prostate cancer in the Japanese population is linked genetically
Prostate Cancer - Most men take preventive measures against prostate cancer
Prostate Cancer - NDA submitted for 6-month prostate cancer product
Prostate Cancer - Nadir PSA can predict progression to androgen-independent prostate cancer
Prostate Cancer - One-on-one support helps prostate cancer survivors
Prostate Cancer - Reolysin kills tumor cells without damaging healthy tissue, study shows
Prostate Cancer - Researchers find genetic subtypes of prostate cancer
Prostate Cancer - Satraplatin shows in vitro efficacy in taxane-resistant tumor cells
Prostate Cancer - Selenium disrupts androgen receptor signaling in prostate cancer
Prostate Cancer - Study analyzes proteins from neoplastic prostate epithelium
Radiology - Radiation safety guidelines are needed for sentinel lymph node procedures
Receptor Studies - Epigallocatechin-3 gallate blocks VEGF-mediated cell proliferation
Renal Cell Carcinoma - Renal cell carcinoma can arise in transplanted kidneys
Reproductive Medicine - Breast cancer patient's frozen, then reimplanted, ovarian tissue yields embryo
Skin Cancer - Study suggests an alternative method to evaluate sunscreens protective ability
Smoking Cessation - Graphic "Smoking Teens" show effects of tobacco products
Splenic Lymphoma - Low-dose cladribine led to good response in patients with splenic lymphomas
Stem-Cell Transplantation - Post-SCT eosinophilic pustular folliculitis described
Stem-Cell Transplantation - Th1 immune response associated with acute GVHD
Stem-Cell Transplantation - Two-loci or greater HLA mismatch associated with poor SCT outcome
Synthetic Peptide - Hyaluronan-binding peptide binds with Bcl-2 to initiate cell death
Testicular Cancer - Cigarette smoking influences testicular cancer risk
Tongue Cancer - P34cdc2 expression predicts poor prognosis in tongue carcinoma
Transplant Medicine - Central nervous system PTLDs characterized
Transplant Medicine - New drugs limit deadly effects of graft-vs.-host disease
Urologic Disorders - Predictive medicine should include malignant, nonmalignant urological disorders
Urological Cancer - Familial incidence increases risk of developing urological cancers
Vaccine Development - New vaccine eliminates IL-6 immune response
Vascular Endothelial Growth Factor - The protein cdk5 may play an important role in endothelial cell regulation
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