Cancer Therapy

New study distinguishes drug-induced from apoptosis-associated DNA damage

Published in Cancer Weekly, March 23rd, 2004

A new study has distinguished DNA damage caused by cancer-fighting drugs from the damage to DNA that occurs as a consequence of apoptosis, i.e., natural cell death. The authors of the study used cytometry measurement of a phosphorylated histone to detect and quantify DNA damage in individual cells.

The study was published March 5, 2004, in the online edition of the journal Cytometry, Part A, and is available via Wiley InterScience (www.interscience.wiley.com/journal/cytometry).

DNA damage, in the form of double-strand breaks, can be caused by radiation, antitumor drugs, or by naturally occurring apoptosis. The damage signals phosphorylation of...

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Source: Cancer Weekly (2004-03-23)

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