HIV/AIDS Cancer
HIV Tat linked to liver tumor development
Published in Cancer Weekly, March 23rd, 2004
"The human immunodeficiency virus type 1 (HIV-1) Tat protein stimulates cell proliferation, inhibits apoptosis, displays angiogenic functions and is believed to be involved in the pathogenesis of Kaposi sarcoma (KS) and other tumors arising in AIDS patients," oncologists in Italy explained. "Tat-transgenic (TT) mice, which constitutively express Tat in all tissues and organs, may therefore be predisposed to tumorigenesis."
"To test this hypothesis," G. Altavilla and colleagues at the University of Ferrara "treated TT mice with urethane, a general carcinogen...
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Source: Cancer Weekly (2004-03-23)
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