Endocrinology
Insulin receptor substrates play a major role in pancreatic cancer angiogenesis
Published in Cancer Weekly, March 23rd, 2004
According to recent research published in the Journal of Biological Chemistry, "vascular permeability factor/vascular endothelial growth factor (VPF/VEGF), the critical molecule in tumor angiogenesis, is regulated by different stimuli such as hypoxia and oncogenes, and also by growth factors. Previously we have shown that in AsPC-1 pancreatic adenocarcinoma cells, insulin-like growth factor receptor (IGF-IR) regulates VPF/VEGF expression. Insulin receptor substrate-1 and -2 (IRS-1 and IRS-2), two major downstream molecules of IGF-1R, are known to be important in the genesis of...
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Source: Cancer Weekly (2004-03-23)
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