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Cancer Weekly

Susan Hasty, Publisher
Table of Contents . . . April 6th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Cancer Weekly | Other Publications

Colon Cancer - "Switched-off" genes put first chink in colon cell's antitumor armor

Lung Cancer - Research explains why anticancer treatment effective for some, not others

Breast Cancer - Breast biopsy specimens can be evaluated with proteomic analysis

HIV/AIDS Cancer - Chemotherapy and HAART feasible for HIV-NHL patients

Leukemia - Combo of two natural toxins may be novel treatment for blood cancer

Prostate Cancer - Obesity drug inhibits prostate tumor growth

Tumor Suppression - Tumor suppressor regulates mitosis by inhibiting APC-Cdc20 complex

Acute Myeloid Leukemia - Cloretazine receives Fast Track designation from FDA

Bladder Cancer - Drinking well water is associated with bladder cancer in Argentina

Bladder Cancer - Tumor suppressor genes predict bladder cancer future

Bone Disease - Skeletal imaging agent approved by FDA

Brain Cancer - Hudson licenses radiosensitizer IPdR

Brain Cancer - Ritonavir treatment may benefit glioblastoma patients

Breast Cancer - Breast cancer foundation honors four leaders

Breast Cancer - Breast cancer patients switched to Aromasin more likely to remain cancer free

Breast Cancer - Caelyx demonstrates efficacy, reduced cardiac toxicity

Breast Cancer - Counseling and education can increase anxiety in some breast cancer patients

Breast Cancer - Epigenetic silencing of adhesion molecule ADAM23 occurs often in breast tumors

Breast Cancer - Epirubicin, vinorelbine, and cisplatin are effective in advanced breast cancer

Breast Cancer - First large-scale trial of genetically personalized treatment to start soon

Breast Cancer - Lamivudine helps keep HBV at bay during cancer chemotherapy

Breast Cancer - Letrozole extends time to tumor progression in mouse model

Breast Cancer - MEP calls for European strategy in the fight against breast cancer

Breast Cancer - Male carriers of germline mutations in BRCA2 are at increased risk for cancer

Breast Cancer - Mammography may not be appropriate for some cognitively impaired women

Breast Cancer - Multidisciplinary approach to care might reduce time between diagnosis, therapy

Breast Cancer - NDA filed with FDA for nanoparticle-based Abraxane

Breast Cancer - New type of breast tumor might respond to prostate cancer drugs

Breast Cancer - Older people lose out all around in breast cancer treatment and care

Breast Cancer - Oncologist calls for new guidelines on early reporting from clinical trials

Breast Cancer - Oncologist says disease is a public health problem in Brazil

Breast Cancer - Overexpressed VEGF₁₂₁ improves oxygenation in certain breast tumors

Breast Cancer - Paperwork interferes with occupational therapists' patient assessments

Breast Cancer - Patent granted for mammary aspirate specimen cytology test

Breast Cancer - Patients unhappy with follow-up visits to oncologists

Breast Cancer - Pre-operative chemotherapy boosts breast conservation by up to 30%

Breast Cancer - Preoperative treatment with anastrozole reduces need for extensive surgery

Breast Cancer - Prospective trial shows modest benefit of tamoxifen after adjuvant chemotherapy

Breast Cancer - Radiotherapy increases CVD risk but to lesser degree with improvements

Breast Cancer - Rates of conservation surgery vary widely among countries

Breast Cancer - Results of comparison study favor exemestane for advanced disease

Breast Cancer - Screening efforts in Egypt yield higher detection rates

Breast Cancer - Study confirms conservation surgery is safe for BRCA cancers

Breast Cancer - Study demonstrates clear survival benefit of treatment in clinical trials

Breast Cancer - Study finds no link between melatonin levels and decreased cancer risk

Breast Cancer - Study highlights importance of diet in disease prevention

Breast Cancer - Study: Breast-conserving surgery viable option for cancer involving nipple/areola

Breast Cancer - Study: Patients switched to AROMASIN more likely to remain cancer-free

Breast Cancer - Survival rates same for conservation treatment or mastectomy for recurrent DCIS

Breast Cancer - Teenager's poetry booklet helps children cope with mothers' breast cancer

Breast Cancer - Treatment of ductal carcinoma in situ varies widely in United States

Breast Cancer - Tumor characteristics may help predict survival

Breast Cancer - Younger survivors suffer more long-term after effects

Breast Cancer Prognosis - Thymidylate synthase mRNA predicts shorter survival in breast cancer

Business & Finance - $1.7M award for cardiac safety monitoring and services announced

Business & Finance - Biotechnology company announces series B financing and new appointments

Business & Finance - FluMist maker announces plan to achieve $2 billion in revenues by 2009

Business & Finance - Lymphoseek maker reports annual revenue increase of 32%

Business & Finance - Scripps Research Institute plans Florida research hospital

Cancer - Commercial agreement announced for cancer vaccine product candidate

Cancer Genetics - Breast cancer gene carriers not at greater risk of relapse

Cancer Genetics - Diagnostic tool enables analysis of molecular characteristics of breast tumors

Cancer Genetics - Metastases share similar genetic profile to primary breast cancer tumor

Cancer Growth Factor - Angiogenic cytokine and endostatin levels are linked in breast cancer patients

Cancer Mortality - Pharmaceutical plant workers have no excess mortality

Cancer Prevention - The Behavioral Oncology Interest Group reports on their annual meeting

Cancer Risk - Radiation after prostate cancer recurrence benefits high-risk patients

Cancer Screening - 'Young'-type breast tissue in older women can thwart breast cancer detection

Cancer Therapy - Company receives approval for Paxene in Europe

Cancer Therapy - Electric pulses show promise for healing or killing unhealthy cells

Cancer Therapy - Genetronics engages CRO for U.S. and European clinical trials

Cancer Therapy - New peptide conjugates could specifically target tumor vessel endothelial cells

Cancer Therapy - Nurses recognize and try to meet psychological needs of chemotherapy patients

Cancer Therapy - Renal cancer human trial of phenoxodiol in combination therapy begins

Cancer Therapy - Researcher developing tumor identification system for surgery

Cancer Therapy - Study evaluates the 2-week wait rule for cancer referral in the U.K.

Cancer Therapy - Valproic acid impedes angiogenesis in laboratory assays and study models

Cancer Therapy - XR5967 alters tumor cell invasion and angiogenesis in vitro

Cardiovascular Disease - Role of ABCA1 in cholesterol metabolism reviewed

Caregivers - Parents of young adults with cancer need to interact with health professionals

Cervical Cancer - CDH1 and CDH13 methylation is a marker for more aggressive cervical cancer

Cervical Cancer - ThinPrep launched at Pacific Rim Pathology Laboratory

Chemotherapy-Induced Nausea - Aloxi injection incorporated into NCCN antiemetic guidelines

Chronic Lymphocytic Leukemia - Preliminary results of Xcytrin for chronic lymphocytic leukemia announced

Collaborations - Alliance to focus on cancer drug study

Collaborations - Company expands pipeline to include obesity, oncology therapies

Collaborations - Genaera extends alliance IL-9 alliance

Colon Cancer - Cancer-care services company announces participation in colon cancer trials

Colon Cancer - New guidelines for hereditary nonpolyposis colorectal cancer are released

Colon Cancer - Phase II colorectal vaccine trial results updated

Colorectal Cancer - Quality of life after rectal surgery needs to be assessed in clinical trials

Complementary & Alternative Medicine - Alternative medicines can pose risks for cancer patients

Complementary & Alternative Medicine - Expert: CAMs have palliative, but not therapeutic, role in breast cancer care

Complementary & Alternative Medicine - Grape seed extract demonstrates antiangiogenic potential in cultured cells

Complementary & Alternative Medicine - More breast cancer patients seeking little-understood CAM therapies

Complementary & Alternative Medicine - Study identifies characteristics of breast cancer patients who use CAM

Coronary Stents - Study shows CYPHER stent yields strong results without pre-dilatation

Diagnostics - Few cancer patients with major depression are treated

Diagnostics - IMPATH enters into national agreement with Humana

Diagnostics - Tumor measurement with 3-D ultrasound is affected by ultrasound focus

Disease Management - Matria Healthcare awarded two new disease management accounts

Drug Development - 2'-Benzoyl-oxycinnamaldehyde is a strong cancer treatment candidate

Drug Development - Artemisinin-derived trioxane dimers have potent antimalarial/anticancer activity

Drug Development - Epidermal growth factor receptor inhibitors should stall cancer growth

Endocrinology - Calcitonin measurements detect medullary thyroid cancer in nodular goiters

Endocrinology - Estradiol stimulates progression factors to cause pituitary adenoma growth

Endocrinology - The tyrosine kinase inhibitor PTK787/ZK222584 staunches thyroid cancer growth

Environment & Health - Study suggests arsenic exposure alters estrogen signaling

Esophageal Cancer - Bacteria are indigenous to esophagus

Esophageal Cancer - Barrett esophagus leads to an increased incidence of esophageal carcinoma

Ethics - Tissue donation should balance patients' rights and researchers' needs

Finance - Biopharmaceutical company reports 2003 financial results

Finance - Biotechnology company completes $23.1M series B financing

Finance - Company reports net income of $38.1 million for year

Finance - Vaccine development helps drive company's 25% revenue increase in 2003

Gallbladder Cancer - Surgical resection for pT2 gallbladder carcinomas yields good 5-year survival

Gastroenterology - Angiopoietin-2 at deep rectal cancer invasion sites affirms a poor prognosis

Gastroenterology - Microarray distinguishes the molecular signatures of hepatocellular carcinomas

Gastroenterology - Pioglitazone prevents hepatic steatosis in animal models

Gastrointestinal Sarcoma - Organization announces release of task force report on gastrointestinal stromal tumors

Gene Suppression - Bcl-2 small interfering RNA halts human tumor cell growth

Geratrics - Cancer patients benefit from a comprehensive geriatric assessment

Geriatrics - Ovarian cancer treatment in elderly patients is often suboptimal

Glioblastoma - Tumor cell p53 function mediates endothelial cell radiosensitivity

Glioma - Brain cancer gene identified

Heart Failure - Implantable defibrillators reduce death by 23% in trial

Heathcare Coverage - Radiofrequency ablation for liver cancer approved for reimbursement in Japan

Hematologic Cancer - Lymphohematopoietic cancer may be related to Alachlor exposure

Hematology - B-chronic lymphocytic leukemia cells express all three VEGF receptors

Hormone Replacement Therapy - Fewer, but more advanced, colon cancers occur in postmenopausal women on HRT

Human Papillomavirus - Researchers propagate infectious HPV16

Hyperparathyroidism - Sensipar wins FDA approval

Immunology - CpG oligonucleotides elicit antitumor responses in melanoma models

Immunology - Myeloperoxidase expression identifies acute myeloblastic leukemia variants

Ischemia - Hepatocyte growth factor ameliorates perfusion without boosting tumor growth

Leukemia - Failure of DNA repair mechanism precedes final stage of deadly leukemia

Licensing Agreement - Geron Corp. inks agreement for therapeutic cancer-vaccine technology

Liver Cancer - Rare metastatic brain lesions can arise from hepatocellular carcinoma

Lung Cancer - Gefitinib targets tyrosine kinase in non-small cell lung cancer

Lung Cancer - PT-100 phase II trial initiated for advanced non-small cell lung cancer

Lung Cancer - Research aims to create lung cancer blood tests

Lung Cancer - Telcyta non-small cell lung cancer trial initiated

Lymphoma - Adding drug to standard chemo improves treatment

Malignant Melanoma - Cutaneous malignant melanoma is increasing worldwide

Melanoma - Board recommends continuations of Canvaxin phase III trial

Melanoma - Study exhibits prognostic value of imaging assay in primary, metastatic melanoma

Metastasis - Downregulated BRCA1 in melanoma modifies its metastatic potential

Mucositis - Mucosal cyclooxygenase-2 expression enhances radiation-induced mucositis

Multiple Myeloma Therapy - Busulphan-cyclophosphamide conditioning safe, effective for auto-SCT

Myelodysplastic Syndrome - Dacogen clinical study interim data clarification released

Myeloma - Simvastatin given with cytotoxic drugs is advantageous in myeloma cell lines

Neuroscience - Human glial fibrillary acidic promoter regulates transgenes in the brain

Non-Hodgkin Lymphoma - Phase I clinical trial of PPI-2458 in non-Hodgkin lymphoma on hold

Obstetrics - Factor V gene polymorphisms leave Finnish women vulnerable to preeclampsia

Oncology - Double-ablated adenovirus has an affinity with tumor targets

Oncology - Interleukin-15 enhances the antitumor efficacy of CD8+ T Cells

Oncology - Interleukin-18 associates with a poor prognosis in multiple myeloma patients

Oncology - Sp1 causes Bcl-2 to modulate urokinase plasminogen activator receptor levels

Pancreatic Cancer - Chemotherapy offers hope for pancreatic cancer patients

Patents - Patents granted for breast marking technology

Pediatric Cancer - Environmental elements cause neuroblastoma to self-destruct

Personnel - Company announces organizational changes

Personnel - Genencor's Jean-Jacques Bienaime joins board of neuropathic pain company

Personnel - Immunotherapy company appoints Claude Miller vice president of quality

Personnel - Isaac Kier joins board

Personnel - Life science company announces new member of board of directors

Personnel - Pharmaceutical company announces new member of corporate advisory board

Personnel - Pharmaceutical company announces new vice president, clinical development

Personnel - Pharmaceutical company appoints new senior VP and chief medical officer

Prostate Cancer - Can a plant that acts like poison ivy cure prostate cancer?

Prostate Cancer - Four-month prostate cancer product approved in Canada

Prostate Cancer - IMRT and image-guided tumor localization improve radiotherapy in prostate cancer

Prostate Cancer - Novel marker may lead to earlier diagnosis and fewer repeat biopsies

Prostate Cancer - Radiation effective for some prostate patients with recurrent cancer

Prostate Cancer - Telomerase expression may be a marker for prostate cancer

Psoriasis - Combination of medication, light therapy increases presence of HPV in skin

Radiology - MR imaging of toxoplasmosis encephalitis in BMT recipients characterized

Rectal Cancer - Combining ultrasound and radiotherapy is safe and effective in rectal cancer

Rectal Cancer - Sphincter preservation should be the goal after anterior rectal resection

Renal Cell Cancer - IFN-producing cytotoxic T cells may mediate stem-cell graft-vs-tumor effect

Rheumatology - Arthritis suppressor genes TIA-1 and TTP vanquish arthritogenic cytokines

Shwachman-Diamond Syndrome - Successful unrelated BMT reported in SDS patient with leukemia

Solid Tumors - 2-Deoxy-D-Glucose phase I trial initiated for solid tumor treatment

Solid Tumors - Patent issued for VTAs that target vascular endothelial growth factor

Squamous Cell Carcinoma - Docetaxel, cisplatin and 5-FU are effective in squamous cell carcinoma

Stem-Cell Transplantation - Young female bone marrow recipients have high risk of ovarian damage

Supplement - JUVEN added to Ross Products' line

Transfusion Medicine - Autologous MDS cells can reconstitute erythrocyte populations after DLI

Transplant Medicine - Immune cells fight cancer's return, predict outcome after stem-cell transplant

Tumor Suppression - ARRY-142886 cleared to advance into human clinical trials

Vaccine Efficacy - Vaccination for neurotropic disease recommended in children with brain tumors

Vaccine Efficacy - Vaccine improves antibody levels in hematopoietic cell transplant patients

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