Cancer Weekly
Susan Hasty, Publisher
Table of Contents . . . April 6th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Colon Cancer - "Switched-off" genes put first chink in colon cell's antitumor armor
Lung Cancer - Research explains why anticancer treatment effective for some, not others
Breast Cancer - Breast biopsy specimens can be evaluated with proteomic analysis
Leukemia - Combo of two natural toxins may be novel treatment for blood cancer
Prostate Cancer - Obesity drug inhibits prostate tumor growth
Tumor Suppression - Tumor suppressor regulates mitosis by inhibiting APC-Cdc20 complex
Acute Myeloid Leukemia - Cloretazine receives Fast Track designation from FDA
Bladder Cancer - Drinking well water is associated with bladder cancer in Argentina
Bladder Cancer - Tumor suppressor genes predict bladder cancer future
Bone Disease - Skeletal imaging agent approved by FDA
Brain Cancer - Hudson licenses radiosensitizer IPdR
Brain Cancer - Ritonavir treatment may benefit glioblastoma patients
Breast Cancer - Breast cancer foundation honors four leaders
Breast Cancer - Breast cancer patients switched to Aromasin more likely to remain cancer free
Breast Cancer - Caelyx demonstrates efficacy, reduced cardiac toxicity
Breast Cancer - Counseling and education can increase anxiety in some breast cancer patients
Breast Cancer - Epigenetic silencing of adhesion molecule ADAM23 occurs often in breast tumors
Breast Cancer - Epirubicin, vinorelbine, and cisplatin are effective in advanced breast cancer
Breast Cancer - First large-scale trial of genetically personalized treatment to start soon
Breast Cancer - Lamivudine helps keep HBV at bay during cancer chemotherapy
Breast Cancer - Letrozole extends time to tumor progression in mouse model
Breast Cancer - MEP calls for European strategy in the fight against breast cancer
Breast Cancer - Male carriers of germline mutations in BRCA2 are at increased risk for cancer
Breast Cancer - Mammography may not be appropriate for some cognitively impaired women
Breast Cancer - Multidisciplinary approach to care might reduce time between diagnosis, therapy
Breast Cancer - NDA filed with FDA for nanoparticle-based Abraxane
Breast Cancer - New type of breast tumor might respond to prostate cancer drugs
Breast Cancer - Older people lose out all around in breast cancer treatment and care
Breast Cancer - Oncologist calls for new guidelines on early reporting from clinical trials
Breast Cancer - Oncologist says disease is a public health problem in Brazil
Breast Cancer - Overexpressed VEGF121 improves oxygenation in certain breast tumors
Breast Cancer - Paperwork interferes with occupational therapists' patient assessments
Breast Cancer - Patent granted for mammary aspirate specimen cytology test
Breast Cancer - Patients unhappy with follow-up visits to oncologists
Breast Cancer - Pre-operative chemotherapy boosts breast conservation by up to 30%
Breast Cancer - Preoperative treatment with anastrozole reduces need for extensive surgery
Breast Cancer - Prospective trial shows modest benefit of tamoxifen after adjuvant chemotherapy
Breast Cancer - Radiotherapy increases CVD risk but to lesser degree with improvements
Breast Cancer - Rates of conservation surgery vary widely among countries
Breast Cancer - Results of comparison study favor exemestane for advanced disease
Breast Cancer - Screening efforts in Egypt yield higher detection rates
Breast Cancer - Study confirms conservation surgery is safe for BRCA cancers
Breast Cancer - Study demonstrates clear survival benefit of treatment in clinical trials
Breast Cancer - Study finds no link between melatonin levels and decreased cancer risk
Breast Cancer - Study highlights importance of diet in disease prevention
Breast Cancer - Study: Breast-conserving surgery viable option for cancer involving nipple/areola
Breast Cancer - Study: Patients switched to AROMASIN more likely to remain cancer-free
Breast Cancer - Survival rates same for conservation treatment or mastectomy for recurrent DCIS
Breast Cancer - Teenager's poetry booklet helps children cope with mothers' breast cancer
Breast Cancer - Treatment of ductal carcinoma in situ varies widely in United States
Breast Cancer - Tumor characteristics may help predict survival
Breast Cancer - Younger survivors suffer more long-term after effects
Breast Cancer Prognosis - Thymidylate synthase mRNA predicts shorter survival in breast cancer
Business & Finance - $1.7M award for cardiac safety monitoring and services announced
Business & Finance - Biotechnology company announces series B financing and new appointments
Business & Finance - FluMist maker announces plan to achieve $2 billion in revenues by 2009
Business & Finance - Lymphoseek maker reports annual revenue increase of 32%
Business & Finance - Scripps Research Institute plans Florida research hospital
Cancer - Commercial agreement announced for cancer vaccine product candidate
Cancer Genetics - Breast cancer gene carriers not at greater risk of relapse
Cancer Genetics - Diagnostic tool enables analysis of molecular characteristics of breast tumors
Cancer Genetics - Metastases share similar genetic profile to primary breast cancer tumor
Cancer Growth Factor - Angiogenic cytokine and endostatin levels are linked in breast cancer patients
Cancer Mortality - Pharmaceutical plant workers have no excess mortality
Cancer Prevention - The Behavioral Oncology Interest Group reports on their annual meeting
Cancer Risk - Radiation after prostate cancer recurrence benefits high-risk patients
Cancer Screening - 'Young'-type breast tissue in older women can thwart breast cancer detection
Cancer Therapy - Company receives approval for Paxene in Europe
Cancer Therapy - Electric pulses show promise for healing or killing unhealthy cells
Cancer Therapy - Genetronics engages CRO for U.S. and European clinical trials
Cancer Therapy - New peptide conjugates could specifically target tumor vessel endothelial cells
Cancer Therapy - Nurses recognize and try to meet psychological needs of chemotherapy patients
Cancer Therapy - Renal cancer human trial of phenoxodiol in combination therapy begins
Cancer Therapy - Researcher developing tumor identification system for surgery
Cancer Therapy - Study evaluates the 2-week wait rule for cancer referral in the U.K.
Cancer Therapy - Valproic acid impedes angiogenesis in laboratory assays and study models
Cancer Therapy - XR5967 alters tumor cell invasion and angiogenesis in vitro
Cardiovascular Disease - Role of ABCA1 in cholesterol metabolism reviewed
Caregivers - Parents of young adults with cancer need to interact with health professionals
Cervical Cancer - CDH1 and CDH13 methylation is a marker for more aggressive cervical cancer
Cervical Cancer - ThinPrep launched at Pacific Rim Pathology Laboratory
Chemotherapy-Induced Nausea - Aloxi injection incorporated into NCCN antiemetic guidelines
Chronic Lymphocytic Leukemia - Preliminary results of Xcytrin for chronic lymphocytic leukemia announced
Collaborations - Alliance to focus on cancer drug study
Collaborations - Company expands pipeline to include obesity, oncology therapies
Collaborations - Genaera extends alliance IL-9 alliance
Colon Cancer - Cancer-care services company announces participation in colon cancer trials
Colon Cancer - New guidelines for hereditary nonpolyposis colorectal cancer are released
Colon Cancer - Phase II colorectal vaccine trial results updated
Colorectal Cancer - Quality of life after rectal surgery needs to be assessed in clinical trials
Complementary & Alternative Medicine - Alternative medicines can pose risks for cancer patients
Complementary & Alternative Medicine - Expert: CAMs have palliative, but not therapeutic, role in breast cancer care
Complementary & Alternative Medicine - Grape seed extract demonstrates antiangiogenic potential in cultured cells
Complementary & Alternative Medicine - More breast cancer patients seeking little-understood CAM therapies
Complementary & Alternative Medicine - Study identifies characteristics of breast cancer patients who use CAM
Coronary Stents - Study shows CYPHER stent yields strong results without pre-dilatation
Diagnostics - Few cancer patients with major depression are treated
Diagnostics - IMPATH enters into national agreement with Humana
Diagnostics - Tumor measurement with 3-D ultrasound is affected by ultrasound focus
Disease Management - Matria Healthcare awarded two new disease management accounts
Drug Development - 2'-Benzoyl-oxycinnamaldehyde is a strong cancer treatment candidate
Drug Development - Artemisinin-derived trioxane dimers have potent antimalarial/anticancer activity
Drug Development - Epidermal growth factor receptor inhibitors should stall cancer growth
Endocrinology - Calcitonin measurements detect medullary thyroid cancer in nodular goiters
Endocrinology - Estradiol stimulates progression factors to cause pituitary adenoma growth
Endocrinology - The tyrosine kinase inhibitor PTK787/ZK222584 staunches thyroid cancer growth
Environment & Health - Study suggests arsenic exposure alters estrogen signaling
Esophageal Cancer - Bacteria are indigenous to esophagus
Esophageal Cancer - Barrett esophagus leads to an increased incidence of esophageal carcinoma
Ethics - Tissue donation should balance patients' rights and researchers' needs
Finance - Biopharmaceutical company reports 2003 financial results
Finance - Biotechnology company completes $23.1M series B financing
Finance - Company reports net income of $38.1 million for year
Finance - Vaccine development helps drive company's 25% revenue increase in 2003
Gallbladder Cancer - Surgical resection for pT2 gallbladder carcinomas yields good 5-year survival
Gastroenterology - Angiopoietin-2 at deep rectal cancer invasion sites affirms a poor prognosis
Gastroenterology - Microarray distinguishes the molecular signatures of hepatocellular carcinomas
Gastroenterology - Pioglitazone prevents hepatic steatosis in animal models
Gastrointestinal Sarcoma - Organization announces release of task force report on gastrointestinal stromal tumors
Gene Suppression - Bcl-2 small interfering RNA halts human tumor cell growth
Geratrics - Cancer patients benefit from a comprehensive geriatric assessment
Geriatrics - Ovarian cancer treatment in elderly patients is often suboptimal
Glioblastoma - Tumor cell p53 function mediates endothelial cell radiosensitivity
Glioma - Brain cancer gene identified
Heart Failure - Implantable defibrillators reduce death by 23% in trial
Heathcare Coverage - Radiofrequency ablation for liver cancer approved for reimbursement in Japan
Hematologic Cancer - Lymphohematopoietic cancer may be related to Alachlor exposure
Hematology - B-chronic lymphocytic leukemia cells express all three VEGF receptors
Hormone Replacement Therapy - Fewer, but more advanced, colon cancers occur in postmenopausal women on HRT
Human Papillomavirus - Researchers propagate infectious HPV16
Hyperparathyroidism - Sensipar wins FDA approval
Immunology - CpG oligonucleotides elicit antitumor responses in melanoma models
Immunology - Myeloperoxidase expression identifies acute myeloblastic leukemia variants
Ischemia - Hepatocyte growth factor ameliorates perfusion without boosting tumor growth
Leukemia - Failure of DNA repair mechanism precedes final stage of deadly leukemia
Licensing Agreement - Geron Corp. inks agreement for therapeutic cancer-vaccine technology
Liver Cancer - Rare metastatic brain lesions can arise from hepatocellular carcinoma
Lung Cancer - Gefitinib targets tyrosine kinase in non-small cell lung cancer
Lung Cancer - PT-100 phase II trial initiated for advanced non-small cell lung cancer
Lung Cancer - Research aims to create lung cancer blood tests
Lung Cancer - Telcyta non-small cell lung cancer trial initiated
Lymphoma - Adding drug to standard chemo improves treatment
Malignant Melanoma - Cutaneous malignant melanoma is increasing worldwide
Melanoma - Board recommends continuations of Canvaxin phase III trial
Melanoma - Study exhibits prognostic value of imaging assay in primary, metastatic melanoma
Metastasis - Downregulated BRCA1 in melanoma modifies its metastatic potential
Mucositis - Mucosal cyclooxygenase-2 expression enhances radiation-induced mucositis
Multiple Myeloma Therapy - Busulphan-cyclophosphamide conditioning safe, effective for auto-SCT
Myelodysplastic Syndrome - Dacogen clinical study interim data clarification released
Myeloma - Simvastatin given with cytotoxic drugs is advantageous in myeloma cell lines
Neuroscience - Human glial fibrillary acidic promoter regulates transgenes in the brain
Non-Hodgkin Lymphoma - Phase I clinical trial of PPI-2458 in non-Hodgkin lymphoma on hold
Obstetrics - Factor V gene polymorphisms leave Finnish women vulnerable to preeclampsia
Oncology - Double-ablated adenovirus has an affinity with tumor targets
Oncology - Interleukin-15 enhances the antitumor efficacy of CD8+ T Cells
Oncology - Interleukin-18 associates with a poor prognosis in multiple myeloma patients
Oncology - Sp1 causes Bcl-2 to modulate urokinase plasminogen activator receptor levels
Pancreatic Cancer - Chemotherapy offers hope for pancreatic cancer patients
Patents - Patents granted for breast marking technology
Pediatric Cancer - Environmental elements cause neuroblastoma to self-destruct
Personnel - Company announces organizational changes
Personnel - Genencor's Jean-Jacques Bienaime joins board of neuropathic pain company
Personnel - Immunotherapy company appoints Claude Miller vice president of quality
Personnel - Isaac Kier joins board
Personnel - Life science company announces new member of board of directors
Personnel - Pharmaceutical company announces new member of corporate advisory board
Personnel - Pharmaceutical company announces new vice president, clinical development
Personnel - Pharmaceutical company appoints new senior VP and chief medical officer
Prostate Cancer - Can a plant that acts like poison ivy cure prostate cancer?
Prostate Cancer - Four-month prostate cancer product approved in Canada
Prostate Cancer - IMRT and image-guided tumor localization improve radiotherapy in prostate cancer
Prostate Cancer - Novel marker may lead to earlier diagnosis and fewer repeat biopsies
Prostate Cancer - Radiation effective for some prostate patients with recurrent cancer
Prostate Cancer - Telomerase expression may be a marker for prostate cancer
Psoriasis - Combination of medication, light therapy increases presence of HPV in skin
Radiology - MR imaging of toxoplasmosis encephalitis in BMT recipients characterized
Rectal Cancer - Combining ultrasound and radiotherapy is safe and effective in rectal cancer
Rectal Cancer - Sphincter preservation should be the goal after anterior rectal resection
Renal Cell Cancer - IFN-producing cytotoxic T cells may mediate stem-cell graft-vs-tumor effect
Rheumatology - Arthritis suppressor genes TIA-1 and TTP vanquish arthritogenic cytokines
Shwachman-Diamond Syndrome - Successful unrelated BMT reported in SDS patient with leukemia
Solid Tumors - 2-Deoxy-D-Glucose phase I trial initiated for solid tumor treatment
Solid Tumors - Patent issued for VTAs that target vascular endothelial growth factor
Squamous Cell Carcinoma - Docetaxel, cisplatin and 5-FU are effective in squamous cell carcinoma
Stem-Cell Transplantation - Young female bone marrow recipients have high risk of ovarian damage
Supplement - JUVEN added to Ross Products' line
Transfusion Medicine - Autologous MDS cells can reconstitute erythrocyte populations after DLI
Transplant Medicine - Immune cells fight cancer's return, predict outcome after stem-cell transplant
Tumor Suppression - ARRY-142886 cleared to advance into human clinical trials
Vaccine Efficacy - Vaccination for neurotropic disease recommended in children with brain tumors
Vaccine Efficacy - Vaccine improves antibody levels in hematopoietic cell transplant patients
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