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Bladder Cancer
Tumor suppressor genes predict bladder cancer future
April 6th, 2004
The presence of two mutated genes in bladder cancer tumors indicates there is a high risk that the cancer will continue grow and spread, says a Baylor College of Medicine (BCM) researcher in a new report. One of the mutated proteins - p53 - is a tumor suppressor that in its normal form prevents cell changes that can lead to cancer. When p53 binds to DNA is stimulates another gene to produce p21. Then p21 interacts with a protein that stimulates cell division. When p21 is in a complex with this protein, the cell cannot go through the next stage of division. Mutations in the genes prevent these protective mechanisms. In this study, published in the...
Source: Cancer Weekly (2004-04-06)
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