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Brain Cancer
Ritonavir treatment may benefit glioblastoma patients
April 6th, 2004
Ritonavir therapy may be beneficial for glioma patients. "Glioblastoma is a therapeutic challenge as a highly infiltrative, proliferative, and resistant tumor," scientists in France explained. "Among novel therapeutic approaches, proteasome inhibition is very promising in controlling cell cycle and inducing apoptosis." In a recent study, N. Laurent and colleagues at INSERM Unit 421 in Creteil "investigated the effect of ritonavir, a protease inhibitor of HIV and a proteasome modulator, on glioma cells." "The hypothesis was that proteasome modulation, mainly by only inhibiting proteasome chymotrypsin-like activity, could be...
Source: Cancer Weekly (2004-04-06)
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