Cancer Weekly
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Breast Cancer
Epigenetic silencing of adhesion molecule ADAM23 occurs often in breast tumors
April 6th, 2004
The adhesion molecule A Desintegrin And Metalloprotease domain 23 gene (ADAM 23) may be downregulated during the progression of breast cancer, researchers say. "Altered cell adhesion is causally involved in tumor progression, and the identification of novel adhesion molecules altered in tumors is crucial for our understanding of tumor biology and for the development of new prognostic and therapeutic strategies," scientists in Brazil report. "Here, we provide evidence for the epigenetic downregulation in breast tumors of the ADAM 23 adhesion molecule, a member of a new family of surface molecules with roles in cell - cell adhesion and/or cell matrix...
Source: Cancer Weekly (2004-04-06)
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