Cancer Weekly
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Colon Cancer
"Switched-off" genes put first chink in colon cell's antitumor armor
April 6th, 2004
Johns Hopkins Kimmel Cancer Center scientists have identified a switched-off family of genes that may prove to be a significant and early dent in a colon cell's anticancer armor. The inactivated genes, called SFRPs - for secreted frizzled-related protein - put the brake on a pathway of cell-growth genes that is an early step en route to cancer. Because the way SFRP genes are altered - through the attachment of so-called methyl groups - is reversible, the findings, reported in the March 14, 2004, advance online edition of Nature Genetics, also suggest potential anticancer value in green tea and other compounds that affect methylation. "SFRP...
Source: Cancer Weekly (2004-04-06)
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