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Breast Cancer

Overexpressed VEGF₁₂₁ improves oxygenation in certain breast tumors

"Vascular endothelial growth factor (VEGF) is an intensively studied molecule that has significant potential, both in stimulating angiogenesis and as a target for antiangiogenic approaches. We utilized MCF-7 breast cancer cells transfected with either of two of the major VEGF isoforms, VEGF₁₂₁ or VEGF₁₆₅ , or fibroblast growth factor-1 (FGF-1) to distinguish the effects of these factors on tumor growth, vascular function, and oxygen delivery," reported researchers in the United States.

"While each transfectant demonstrated substantially increased...

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