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Breast Cancer Prognosis
Thymidylate synthase mRNA predicts shorter survival in breast cancer
April 6th, 2004
The expression of thymidylate synthase mRNA is associated with shorter survival in patients with breast cancer. "Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-time quantitative PCR in a series of 86 micro-selected breast carcinomas and 8 micro-selected tumor-adjacent normal breast epithelial specimens," investigators in China and Norway report. "Highly variable mRNA expressions of...
Source: Cancer Weekly (2004-04-06)
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