Cancer Weekly
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Tumor Suppression
Tumor suppressor regulates mitosis by inhibiting APC-Cdc20 complex
April 6th, 2004
The tumor suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. According to published research from South Korea and the United States, "The tumor suppressor gene RASSF1A is frequently silenced in lung cancer and other sporadic tumors as a result of hypermethylation of a CpG island in its promoter. However, the precise mechanism by which RASSF1A functions in cell cycle regulation and tumor suppression has remained unknown. Here we show that RASSF1A regulates the stability of mitotic cyclins and the timing of mitotic progression." "RASSF1A localizes to microtubules during interphase and to centrosomes and the spindle during...
Source: Cancer Weekly (2004-04-06)
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